| Question 1: A high correlation coefficient implies good agreement..
|
| Reference: | JM Bland, DG Altman, Lancet i: p307-10, 1986
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| Choice A: | True |
| Choice B: | False |
| Question 2: Which of the statements is true? |
| Reference: | *N Altman, M Krzywinski, Nature Methods, 12, p899-900, 2015
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| Choice A: | Correlation is independent of sample size and noise. |
| Choice B: | When the number of features is small with respect to the sample size, large but spurious correlations frequently occur |
| Choice C: | When there is a large number of observations, small and substantively unimportant correlations may appear statistically significant |
| Choice D: | All of the above. |
| Question 3: In a replication study of the same size as the original study... |
| Reference: | Lazzeroni et at, Molecular Psychiatry, 19, 1336-40, 2014 |
| Choice A: | The performance of the originally identified predictive markers is expected to be same. |
| Choice B: | The obtained p-values are expected to be the same. |
| Choice C: | All of the above. |
| Choice D: | None of the above. |
| Question 4: Two studies identified important genes associated with breast cancer survival; the first group identified 76 genes, and the second one identified 70. How many genes did they have in common? |
| Reference: | Ein-Dor et at, PNAS, 103, 5923-28, 2006 |
| Choice A: | 70 |
| Choice B: | 30 |
| Choice C: | 3 |
| Choice D: | None |
| Question 5: “Big data” will automatically lead to a better understanding of the fundamental questions of basic and applied science (incl. radiomics). |
| Reference: | RJ Gillies, PE Kinahan, and H Hricak, Radiology, 278, 563-77, 2016 |
| Choice A: | True. |
| Choice B: | False. |
| Question 6: In a retrospective systematic review of studies on the use of PET or CT texture features in assessment of prognosis/clinical outcome, how many of the 9 studies’ results remained statistically significant after proper statistical re-analysis? |
| Reference: | A Chalkidou, MJ O’Doherty, PK Marsden, PLoS ONE 10(5): e0124165, 2015 |
| Choice A: | All 9 |
| Choice B: | 6 |
| Choice C: | 3 |
| Choice D: | None |
