Dose Verification in a Small Animal Image-Guided Radiation Therapy X-Ray Machine: A Dose Comparison Between TG-61 Based Look-Up Table and MOSFET Method for Various Collimator Sizes
A Rodrigues1*, G Nguyen2, Y Li2, K Roy Choudhury1, D Kirsch2, S Das2, T Yoshizumi2, (1) Duke University, Durham, NC, (2) Duke University Medical Center, Durham, NCSU-E-T-275 Sunday 3:00:00 PM - 6:00:00 PM Room: Exhibit Hall
Purpose: To verify the accuracy of TG-61 based dosimetry with MOSFET technology using a tissue-equivalent mouse phantom.
Methods: Accuracy of mouse dose between a TG-61 based look-up table was verified with MOSFET technology. The look-up table followed a TG-61 based commissioning and used a solid water block and radiochromic film. A tissue-equivalent mouse phantom (2 cm diameter, 8 cm length) was used for the MOSFET method. Detectors were placed in the phantom at the head and center of the body. MOSFETs were calibrated in air with an ion chamber and f-factor was applied to derive the dose to tissue. In CBCT mode, the phantom was positioned such that the system isocenter coincided with the center of the MOSFET with the active volume perpendicular to the beam. The absorbed dose was measured three times for seven different collimators, respectively. The exposure parameters were 225 kVp, 13 mA, and an exposure time of 20 s.
Results: For a 10 mm, 15 mm, and 20 mm circular collimator, the dose measured by the phantom was 4.3%, 2.7%, and 6% lower than TG-61 based measurements, respectively. For a 10 x 10 mm, 20 x 20 mm, and 40 x 40 mm collimator, the dose difference was 4.7%, 7.7%, and 2.9%, respectively.
Conclusions: The MOSFET data was systematically lower than the commissioning data. The dose difference is due to the increased scatter radiation in the solid water block versus the dimension of the mouse phantom leading to an overestimation of the actual dose in the solid water block. The MOSFET method with the use of a tissue-equivalent mouse phantom provides less labor intensive geometry-specific dosimetry and accuracy with better dose tolerances of up to ± 2.7%.