Characterization of the Very High Energy Electrons, 150 - 250 MeV (VHEE) Beam Generated by ALPHA-X Laser Wakefield Accelerator Beam Line for Utilization in Monte Carlo Simulation for Biomedical Experiment Planning
V Moskvin1*, A Subiel2, C Desrosiers1, M Wiggins2, M Maryanski3, M Mendonca1, M Boyd4, A Sorensen4, S Cipiccia2, R Issac2, G Welsh2, E Brunetti2, C Aniculaesei2, D A Jaroszynski2, (1) Department of Radaition Oncology, Indiana University- School of Medicine, Indianapolis, IN, (2) SILIS, Department of Physics, University of Strathclyde, Glasgow, UK,(3) MGS Research, Inc., Madison, CT, (4) SIPBS, University of Strathclyde, Glasgow, (5) Cyclotron Operations, IU Health Protons Therapy Center, Bloomington, INSU-E-T-472 Sunday 3:00:00 PM - 6:00:00 PM Room: Exhibit Hall
Purpose: Progress in the development of compact high-energy pulsed laser-plasma wakefield accelerators is opening up the potential for using Very High Energy Electron (VHEEs) beams in the range of 150 - 250 MeV for biomedical studies. Initial experiments using VHEE for this purpose have been carried out using the ALPHA-X laser-plasma wakefield accelerator beam line at the University of Strathclyde, Glasgow, UK. The purpose of this investigation is to use Monte Carlo simulations to plan experiments and compare with characterization of the interaction of the VHEE beam using a dosimeter.
Methods: An experiment using the VHEE beam to irradiate a muscle-equivalent BANG polymer gel dosimeter has been carried out. Simulations have been used to prepare for the experiments. These were undertaken using the expected average energy for a pulse set and an energy spread approximated by Gaussian distribution. The model was implemented in FLUKA Monte Carlo code with follow up modeling using the Geant4 toolkit. The results have been compared with 1mm^3 voxel laser CT based measurements of the dose deposited in the BANG dosimeter and with measurement of the induced radioactivity.
Results: The results of the measured dose from induced radioactivity have been compared with data from the FLUKA simulations. The beam model based on an average energy of particles in irradiation gives an acceptable estimate of the induced radioactivity and the dose deposited in the BANG dosimeter. Comparison with the dosimeter scanned profiles shows that the structure of the spectra of VHEE beams in the experiment and secondary scattered particles in the beam line should be accounted for in any model. Such model description of the VHEE beam for the ALPHA-X beam line has been developed.
Conclusions: Monte Carlo simulations using the FLUKA code is an efficient way to plan a VHEE experiment and analyze data from measurements.