Determining the Optimal B-Values to Use in Diffusion Weighted Imaging for Differentiating Benign and Malignant Breast Lesions
MA Jacobs1*, (1) The Russell H. Morgan Department of Radiology and Radiological Science and Sidney Kimmel Comprehensive Cancer Center. The Johns Hopkins University School of Medicine, Baltimore, MD 21205SU-E-I-24 Sunday 3:00:00 PM - 6:00:00 PM Room: Exhibit Hall
Purpose: To investigate and determine the optimal b-values for Diffusion Weighted Imaging(DWI) for Apparent Diffusion Coefficient(ADC) maps in differentiating normal, benign and malignant breast tissue.
Methods: Twenty-five patients underwent diffusion-weighted magnetic resonance imaging(DWI-MRI) and conventional breast MRI with suspicious breast findings(BIRADS >4). Breast lesions were defined by pathology. The DWI was acquired with different b-values ranging from 0,500, 600,750 and 1000s/mm². Apparent Diffusion Coefficient(ADC) maps of breast tissue were constructed using different b-values, e.g., using either 2 b-values(0-1000) or combinations of 3 or more (0,500,1000 or 0,600,750,1000). Quantitative analyses of the ADC maps of glandular, fatty and lesion tissue were obtained. Ratios of lesion to glandular tissue(L/GT) and signal to noise(SNR) were assessed. Paired t-tests were performed for statistical significance.
Results: Eighteen patients had invasive ductal carcinoma and 7 had benign breast lesions. The mean ADC value for malignant lesions using all b values was 1.17±0.16x10-3mm²/s with a lesion to glandular(L/GT) ratio=0.65. The benign lesions, ADC map value was 1.86±0.03x10-3mm²/s with L/GT=0.98. There was a significant difference(P<0.05) between benign and malignant lesions ADC map value.The lowest SNR(12±6) was with single b-values. There was a significant difference(P<0.05) in SNR with multiple b-values(34±6) compared to single b-values. The highest SNR was given by using two b values greater than 500. Finally, the background noise for all combinations was surprising stable and ranged between 60±20%.
Conclusions: This is the first study to investigate the effect of changing different b values in DWI breast imaging. There were significant differences in the SNR between single and multiple b values. Our data show suggest that the recommended b-values for DWI in breast are 0, and two that are 500 or greater. Therefore use of at least 3 b-values in DWI/ADC mapping of breast lesions are needed for better characterization of benign and malignant breast tissue.