Evaluation of the Effects of Dose On 4DCT-Calculated Lung Ventilation
K Latifi*, T Dilling, S Hoffe, C Stevens, E Moros, G Zhang, H. Lee Moffitt Cancer Center, TAMPA, FLSU-E-J-187 Sunday 3:00:00 PM - 6:00:00 PM Room: Exhibit Hall
Purpose: To investigate the effects of radiation therapy (RT) treatment dose on ventilation.
Methods: Optical flow deformable image registration of the normal end-expiration and end-inspiration phases of 4DCT images was used to correlate the voxels between the two phases. 4DCT sets from before and after RT were used to derive ventilation for 3 SBRT lung patients. Planning dose and normalized ventilation were superimposed on the CT volume resulting in each voxel having a volume, a normalized ventilation and a dose. From these values a 3D dose-ventilation-volume surfaces was created. The surface was integrated over dose to reduce the 3D surface to a 2D histogram that is easier to interpret.
Results: For lung tissue regions receiving more than 20 Gy, a decrease in ventilation was observed in the three patients. Patient A (time between scans, T=26 months) showed an increase in ventilation for regions receiving a dose smaller than 20 Gy, whereas patients B (T=3 months) and C (T=6 months) did not show any change for these regions. Mean ventilation within the 20 Gy region for patient A was 0.57 before RT and 0.51 after RT; and 0.54 before and 0.48 after RT for the 30 Gy region. Mean ventilation for the 20 Gy region for patient B was 0.49 before RT and 0.47 after RT, for the 30 Gy region mean ventilation was 0.49 Gy before and 0.45 Gy after RT. Patient C's mean ventilation for the 20 Gy region was 0.54 before RT and 0.50 after RT, for the 30 Gy region mean ventilation was 0.54 before RT and 0.49 after RT.
Conclusions: Ventilation before and after radiation therapy can be measured using 4DCT and deformable image registration techniques. In a preliminary application of this approach for three patients, changes in ventilation were observed with a weak correlation between ventilation change and dose.