Investigation of Photon and Proton Overlapping Fields in PRESAGE- Dosimeters
M Carroll1,2*, G Ibbott1, R Grant1, J Adamovics3, M Gillin1, (1) UT MD Anderson Cancer Center, HOUSTON, TX, (2) UT Health Science Center Graduate School of Biomedical Sciences at Houston, Houston, TX, (3) Rider University, Skillman, NJSU-E-T-132 Sunday 3:00:00 PM - 6:00:00 PM Room: Exhibit Hall
Purpose: To evaluate the effects of overlapping dose volumes for varying field arrangements in two formulations of PRESAGE®: one intended for, and irradiated with, proton beams and the other photon beams.
Methods: For each treatment modality (photon, proton), three overlapping field setups were performed. These included a stationary dosimeter irradiated over six fractions, a dosimeter shifted laterally to the field to deliver a dose plateau in two fractions, and a dosimeter rotated on its axis to deliver a two-field (for protons) and four-field (for photons) box treatment overlapping in the center of the dosimeter. All subsequent fractions were given within ten minutes and never less than one minute apart. Two cylindrical PRESAGE® dosimeters approximately 7.5 cm in length by 7.5 cm in diameter were irradiated for each setup. The dosimeters were paired, with one dosimeter given total dose by a single fraction while the other followed one of the overlapping field setups. The dosimeters were analyzed using an optical CT scanner and exported to the CERR environment where the doses were compared between paired dosimeters.
Results: Dose profile comparisons showed relative dose agreement between paired dosimeters within 5% along the SOBP region of the proton formulation. In the case of the fractionated proton irradiation, there was an over-response while other setups resulted in under-responses. Dose agreement between the photon dosimeter treated with six fractions showed a dose under-response within 11% and never less than 5%. Future measurements will include the remaining field setups.
Conclusions: The proton formulation of PRESAGE® showed good dose agreement between single and multiple field irradiations. While the photon formulation had slightly less agreement, additional field setup comparisons may show improved results. These results will aid future measurements of overlapping field treatment plans delivered to PRESAGE® for treatment verification for proton and photon 3D dosimetry.