Individualized Trade-Off of Dose Coverage and Sparing in IMRT Planning
L Yuan1*, Y Ge2, T Li1, F Yin1, Q Jackie Wu1, (1) Duke University Medical Center, Durham, NC, (2) Wake Forest University Health Sciences, Winston-Salem, NCSU-E-T-626 Sunday 3:00:00 PM - 6:00:00 PM Room: Exhibit Hall
We present an evidence-based approach to quantifying the dose sparing trade-offs between different Organs-at-risk (OARs) and the trade-off between OAR dose sparing and target dose coverage in IMRT plans.
The interaction between dose sparing of different OARs and between target dose coverage and OAR dose sparing are modeled using high-quality prior IMRT plans of prostate, head-and-neck (HN), and spine SBRT cases. The dose sparing for each OAR is modeled separately at first based on their own anatomical features and then the contributions from other OARs or PTV are added into the model to account for the possible trade-off effects in plans whose modeled OAR DVH deviates from that of actual plans.
The most significant OAR dose sparing trade-off is between bladder and rectum in prostate plans and between the left and the right parotids in HN plans. Trade-off is most apparent when the parotid on one side has very large overlap with the PTV. In most of these plans (83%), the planer chooses to loosen the dose constraint for that parotid in exchange for lower contra-lateral parotid median dose. The interaction between OAR dose sparing and PTV dose coverage is most significant in spine SBRT plans, (R2=0.37). Another important factor is the tightness of the geometric enclosure of PTV around OAR (R2=0.38).
The dosimetric trade-off between multiple OARs and between PTV and OAR in IMRT planning is quantified by studying prior plans. These findings will help physicians and planners obtain better OAR dose sparing by exploring different trade-off options for individual patient cases.