Effect of MLC Leaf Width On MLC Leaf Shifting Algorithm for Concurrent Treatment of Prostate and Pelvic Lymph Nodes
Q Shang*, P Qi, A Vassil, G Huang, P Xia, The Cleveland Clinic Foundation, Cleveland, OHSU-E-J-22 Sunday 3:00:00 PM - 6:00:00 PM Room: Exhibit Hall
Purpose: Tour previous study showed that adjusting selected MLC leaf pairs to follow prostate movement is an effective strategy to account for daily prostate displacement during concurrent treatment with pelvic lymph nodes. MLC leaf width affects the quality of MLC shifting plans for longitudinal prostate motion compensation. This study is to investigate the effect of the MLC leaf width in compensation of the prostate movement.
Methods: Fifty-one daily CT on-rail scans from three patients were available for this study. On these CTs, the prostate, bladder and rectum were manually contoured, and the lymph nodes contours were transferred from the planning CT after rigid bony registration. For each patient, three different IMRT plans were created based on a planning CT using leaf width of 2.5, 5, and 10 mm, respectively. For each CT, the prostate displacement was determined by dual imaging registration and compensated by shifting MLC resulting in a total of 153 MLC shifted plans.
Results: Among 51 daily CTs, the average prostate movement along the superior/inferior direction was 1.1±3.7 mm (range: -6 to 6.5 mm). The differences in D99 of the prostate between the dose of the day and dose of the plan were 2.3±3.3%, 1.3±2.0%, and 4.4±5.1% for 2.5, 5, and 10 mm leaf width plans, respectively (p<<0.05). The corresponding differences in D99 of the lymph nodes were 0.7±0.9%, 0.6±0.9%, and 1.4±0.8%. The mean differences in D50 were 0.8%, 1.6%, and 2.7% for the bladder, and 10.0%, 3.9%, and 5.7% for the rectum, respectively.
Conclusions: Using the MLC Shifting method to compensate for prostate movement in the longitudinal direction depends on the MLC leaf width and the magnitude of the prostate motion. The use of leaf width of 5 mm can provide sufficient tumor coverage without significantly affecting doses to the critical structures.