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Improved MAGIC Gel for Tissue Equivalence and Dose Sensitivity Using Sucrose

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S Kwon

S Kwon1*, Y Cho2, K Kim3, H Jung4, Y Ji5, (1) Kyonggi University, Suwon, Kyonggi-do, (2) Kyonggi University, Suwon, Kyonggi-do, (3) KIRAMS, Seoul,(4) KIRAMS, Seoul,(5) KIRAMS, Seoul,

SU-E-T-114 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose:
To improve the dose sensitivity and tissue equivalence of MAGIC gel dosimeter, the effect of sucrose as an additive is investigated.

Methods:
For the synthesis of the gel, sucrose was placed in high-purity distilled water (HPLC) and dissolved at room temperature, this was followed by the addition of gelatine. Then, hydroquinone was added and the gel cooled to 40 degree. Lastly, methacrylic acid, ascorbic acid and copper (II) sulfate were added. A Biobeam 8000 (STS, Braunschweig, Germany) Cesium-137 Gamma-ray irradiator was used with a dose rate of 2.6 Gy/m. Magnetic resonance images of the gel were acquired by using a 3.0 T MRI.

Results:
Gels synthesized by adding sucrose to the MAGIC gel displayed increases in carbon content and decreases in oxygen content as the concentration of sucrose increased. When 20% sucrose was added to MAGIC Gel, it was possible to obtain an O/C ratio that matched that of soft tissue within a 5% range. This confirms that the low carbon content in the MAGIC gel could be improved by adding sucrose. Sucrose, as a substance that accelerates the polymerization of monomers, maintains linearity for a wide range of doses. It was possible to obtain a dose sensitivity that is approximately 3.45 times higher in a MAGIC gel dosimeter with a sucrose concentration of 30% compared to one with 0%. It was also possible to confirm that the slope-to-intercept ratio increased as the concentration of sucrose increased.

Conclusion:
Improved MAGIC gel concentrations have higher sensitivity and better elemental tissue equivalency for 3-dimensional dosimetry in radiotherapy field.

Funding Support, Disclosures, and Conflict of Interest: This work was supported by National Foundation of Korea Grant funded by the Korean Government(2011-0030597)

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