Tissue Decomposition From Dual Energy CT Data to Reduce Range Uncertainties in Proton and Carbon Radiotherapy
N Huenemohr1*, H Paganetti2, S Greilich1, O Jaekel1,3, J Seco2, (1) German Cancer Research Center, Heidelberg, (2) Massachusetts General Hospital, Boston, MA, (3) University Hospital of Heidelberg, HeidelbergTH-C-144-3 Thursday 10:30AM - 12:30PM Room: 144
Purpose: To reduce uncertainties in CT data conversion to stopping power ratio (SPR) and tissue composition when using single energy CT (SECT), this study presents a first approach of exploiting dual energy CT (DECT) data for Monte Carlo (MC) based dose calculation in particle therapy.
Methods:DECT image data can be converted into an electron density and effective atomic number image. With both tissue parameters elemental weights of 71 tabulated tissues were predicted by dedicated linear fits for each element. The mass density was derived via a single linear fit of the electron density from adipose on.
Dose calculations with the MC system TOPAS were performed using monoenergetic pencil beams (protons and carbons) stopped in 12 selected tissues which showed considerable differences in composition predictions from single and dual energy CT. Ranges were compared with predictions from the novel DECT approach and the standard SECT.
Results:Predictions of mass density, carbon and oxygen elemental weights profit highly from the additional DECT information. Maximum differences to the true mass density could be reduced from 3.0% (SECT) to 0.9% (DECT) for soft tissue and from 0.7% (SECT) to 0.1% (DECT) for bone tissue. Furthermore, DECT shows a significant improvement also in common tissues: range uncertainties in cartilage were reduced from 1.7% (SECT) to 0.2% (DECT), in yellow marrow from 1.7% (SECT) to 0.5% (DECT), in liver from 0.9% (SECT) to 0.2% (DECT), in brain cerebroisal fluid from 2.2% (SECT) to 0.0% (DECT) and in femur the predicted range deviates by 0.8% (SECT) to 0.0% (DECT) from the true value.
Conclusion:DECT can provide more accurate material compositions and mass density as compared to single energy CT. Therewith, DECT information can significantly reduce range uncertainties in particle therapy and can lead to a reduction in currently applied range margins in proton and carbon ion therapy.