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Normal Tissue Tolerance Evaluation Tool for Clinical Protocols

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S Lee

S Lee1,2*, H Kim1,2, S Han1,2, M Kim1,2,3, H Yoo3, C Yi1,4, S Park2, H Jung1,2, Y Ji1,2, K Kim1,2,3, (1)University of Science & Technology, Daejeon, Korea, (2)Korea Institute of Radiological & Medical Sciences, Seoul, Korea (3)Korea Cancer Center Hospital, Seoul, Korea (4)Korea Research Institute of Standrards and Science, Daejeon, Korea

SU-E-T-711 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose: We developed Graphic User Interface (GUI) to evaluate and verify whether Dose Volume Histogram (DVH) parameters meet clinical protocol criteria.

Methods:A graphical application to import and evaluate DVH parameters was developed by using Matlab (version R2012a, Mathworks). Two DVH text files which were exported from Eclipse treatment planning system (Varian, USA) could be imported, and it automatically depicts DVH values and arranges dose statistics in Eclipse manner (Figure 1). Additionally, it is possible to evaluate not only KIRAMS dose constraint protocol but also currently well-known normal tissue constraint protocol such as American Association of Physicists in Medicine (AAPM), Radiation Therapy Oncology Group (RTOG) and Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC). Those protocols were able to be simultaneously depicted on the DVH so that dose constraints were easily distinguishable.

Results:DVH data analyzed for all organ parameters with the application was faster than manually looking for points using the treatment planning system. Also, since a protocol-specific marker used for evaluating dose constraint, the software was easily able to verify each depicted DVH for different types of patient plans whether under the protocol suggested dose or not (Figure 2).

Conclusion:This software can help the planner to easily decide how much computer-calculated DVH was over/under estimated on the basis of the dose constraints that clinical protocols suggested.

Funding Support, Disclosures, and Conflict of Interest: Acknowledgement : This research was supported by the Ministry of education, Science and Technology(MEST)

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