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Diffuse Optical Tomography for Characterization of Optical Properties in Interstitial PDT

A Sharikova

A Sharikova*, X Liang, T Zhu, Univ Pennsylvania, Philadelphia, PA

SU-E-I-88 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

To characterize spatial distribution of optical properties (OP) for the interstitial photodynamic therapy (PDT) dosimetry using diffuse optical tomography (DOT).

A spatial distribution of interstitial optical properties (absorption and reduced scattering coefficients) in a solid prostate phantom with OP heterogeneities was measured by scanning optical detector and source fibers with a multi-channel motorized system. Several algorithms optimizing the scanning process were developed for the data acquisition system. The calculated light fluence rates were compared with measured ones to recover the heterogeneous optical properties. A mathematical phantom was used to test the reconstruction.

The ability to correctly separate absorption and scattering coefficients depended on the accuracy of the light fluence source measurement. The difference between measured and reconstructed fluence rates was within 10%. The DOT allowed reliable recovery of the absorption coefficients.

The efficacy of PDT depends on the light distribution within the treated tissue. Since the spatial distribution of tissue optical properties affects the light distribution, the accurate determination of the OP spatial distribution is critical for the interstitial PDT treatment.

Funding Support, Disclosures, and Conflict of Interest: This work is supported by the national Institute of Health (NIH) grants P01 CA87971 and R01 CA154562

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