2016 AAPM Annual Meeting
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Session Title: CT Ventilation Imaging: The New Clinical Reality of Functional Avoidance and Response Assessment in Lung Cancer Radiation Therapy
Question 1: Which of the following is (are) required for CT ventilation imaging?
Reference:T. Guerrero, K. Sanders, J. Noyola-Martinez, E. Castillo, Y. Zhang, R. Tapia, R. Guerra, Y. Borghero, R. Komaki, "Quantification of regional ventilation from treatment planning CT," Int J Radiat Oncol Biol Phys 62, 630-634 (2005).
Choice A:4D CT or paired expiratory/inspiratory CT.
Choice B:Inhaled contrast agent.
Choice C:Deformable image registration.
Choice D:Quantitative analysis of regional volume change.
Choice E:A,C,D
Question 2: Which of the following affect(s) the accuracy of CT ventilation imaging?
Reference:T. Yamamoto, S. Kabus, C. Lorenz, E. Johnston, P.G. Maxim, M. Diehn, N. Eclov, C. Barquero, B.W. Loo, Jr., P.J. Keall, "4D CT lung ventilation images are affected by the 4D CT sorting method," Med Phys 40, 101907 (2013).
Choice A:4D CT image artifacts.
Choice B:Deformable image registration errors.
Choice C:Volume of functional lung.
Choice D:Irregular breathing during a 4D CT scan.
Choice E:A,B,D
Question 3: What is the Spearman correlation coefficient when CT ventilation is compared to other lung function imaging modalities?
Reference:Reference: Kipritidis J, Siva S, Hofman MS, et al. Validating and improving CT ventilation imaging by correlating with ventilation 4D-PET/CT using 68Ga-labeled nanoparticles. Medical physics 2014; 41:011910
Choice A:0
Choice B:0.5
Choice C:0.99
Choice D:-0.5
Question 4: What is the theoretical goal of CT ventilation functional avoidance radiotherapy?
Reference:Vinogradskiy Y, Castillo R, Castillo E, et al. Use of 4-Dimensional Computed Tomography-Based Ventilation Imaging to Correlate Lung Dose and Function With Clinical Outcomes. International Journal of Radiation Oncology Biology Physics 2013; 86:366-371
Choice A:Improved local control.
Choice B:Reduced probability of pulmonary toxicity.
Choice C:More conformal dose distribution.
Question 5: Several authors have performed cross-modality validation of CT ventilation imaging. Which statement best describes the differences between these studies?
Reference:T. Yamamoto, S. Kabus, M. Bal, P.J. Keall, S. Benedict, M. Daly, "The first patient treatment of computed tomography ventilation functional image-guided radiotherapy for lung cancer" Radiother Oncol 118(2), 227-31 (2016).
Choice A:Studies can differ in terms of imaging subjects (e.g. animal or human).
Choice B:Studies can differ in terms of reference modality (e.g. SPECT or PET).
Choice C:Studies can differ in terms of validation metric (e.g. Spearman or Dice).
Choice D:All of the above.
Question 6: When comparing the variation of voxel values between two ventilation images, what is the difference between the Pearson correlation and the Spearman correlation?
Reference:• J. Kipritidis, S. Siva, M.S. Hofman, J. Callahan, R. J. Hicks, P. J. Keall, "Validating and improving CT ventilation imaging by correlating with ventilation 4D-PET/CT using 68Ga-labeled nanoparticles" Med Phys 41(1), 12 pages, (2014). • C. Spearman, "The proof and measurement of association between two things" Am J Psychol 15(1), pp. 72-101, (1904).
Choice A:Pearson describes monotonicity; Spearman describes linearity.
Choice B:Pearson describes linearity; Spearman describes monotonicity.
Choice C:Pearson describes linearity; Spearman describes heterogeneity.
Choice D:There is no difference.
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