Question 1: Which of the following PET radiotracers is a hypoxia imaging agent?
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Reference: | Carlin S, Humm JL, PET of Hypoxia: Current and Future Perspectives. J Nucl Med. 2012 Aug;53(8):1171-4. PMID: 22789676.
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Choice A: | Fluorothymidine (FLT) |
Choice B: | Fluoromisonidazole (FMISO) |
Choice C: | Fluordeoxyglucose (FDG) |
Choice D: | Fluoroestradiol (FES) |
Choice E: | Fluoride (NaF) |
Question 2: When measuring the activity of a PET acquisition performed with a hypoxia radiotracer, the voxel intensities within hypoxic tumors relative to background muscle tissue is typically?
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Reference: | Carlin S, Humm JL, PET of Hypoxia: Current and Future Perspectives. J Nucl Med. 2012 Aug;53(8):1171-4. PMID: 22789676. |
Choice A: | Less than 1. |
Choice B: | Between 1 and 3. |
Choice C: | Between 3 and 10. |
Choice D: | Greater than 10. |
Question 3: What are the advantages of metabolic response assessment by FDG PET/CT compared to anatomic response assessment? |
Reference: | 1 R. L. Wahl, Jacene, H. Kasamon, Y., Lodge, M. A., "From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors.," J Nucl Med. 50 122S-150S (2009).
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Choice A: | Metabolic change often occurs earlier than anatomic change. |
Choice B: | Metabolic change is often more substantial than anatomic change. |
Choice C: | There exists strong correlation between FDG uptake and cancer cell number. |
Choice D: | FDG PET/CT allows quantitative assessments . |
Choice E: | All of the above. |
Question 4: In computerized PET analysis or radiomics studies, which type of PET image features was found most prominent for tumor response assessment?
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Reference: | 2 W. Lu, J. Wang, and H. H. Zhang, "Computerized PET/CT Image Analysis in the Evaluation of Tumor Response to Therapy," The British Journal of Radiology. 20140625 (2015).
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Choice A: | Maximal SUV. |
Choice B: | Metabolic tumor volume. |
Choice C: | Heterogeneity in tumor uptake. |
Choice D: | Total lesion glycolysis. |
Question 5: The standardized update value measured in PET is not dependent on |
Reference: | Huang, S.C., Anatomy of SUV. Standardized uptake value. Nucl Med Biol, 2000. 27(7): p. 643-6.
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Choice A: | Patient height. |
Choice B: | Patient weight. |
Choice C: | Injected activity (Bq). |
Choice D: | Measured activity concentration (KBq/ml). |
Choice E: | Calibration of the PET system. |
Question 6: Which one is not correct for average CT? |
Reference: | Pan, T., et al., Attenuation correction of PET images with respiration-averaged CT images in PET/CT. J Nucl Med, 2005. 46(9): p. 1481-7. |
Choice A: | It has a temporal resolution of about one breath cycle. |
Choice B: | It can be used for dose calculation in RT. |
Choice C: | It can be used in registration with CBCT in IGRT. |
Choice D: | It can be derived from 4DCT. |
Choice E: | It has a well-defined boundary for a moving object. |