2017 AAPM Annual Meeting
Back to session list

Session Title: Joint Scientific Symposium with ESTRO: From Bench to Bedside Via Veterinary Radiation Oncology
Question 1: Which tumor type in dogs occurs much more commonly than in human patients having up to a 75 times greater prevalence in the dog?
Reference:Schiffman JD, Breen M. Comparative oncology: what dogs and other species can teach us about humans with cancer. Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19;370(1673). pii: 20140231. doi: 10.1098/rstb.2014.0231. Review. PubMed PMID: 26056372; PubMed Central PMCID: PMC4581033.
Choice A:Glioma.
Choice B:Osteosarcoma.
Choice C:Hodgkin’s lymphoma.
Choice D:Malignant dermal melanoma.
Question 2: T regulatory cells have been found in primary tumors in dogs diagnosed with mucosal melanoma. True or False?
Reference:Monjazeb AM, Kent MS, Grossenbacher SK, Mall C, Zamora AE, Mirsoian A, Chen M, Kol A, Shiao SL, Reddy A, Perks JR, T N Culp W, Sparger EE, Canter RJ, Sckisel GD, Murphy WJ. Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies. Clin Cancer Res. 2016 Sep 1;22(17):4328-40. doi: 10.1158/1078-0432.CCR-15-3026. PubMed PMID: 26979392; PubMed Central PMCID: PMC5010514.
Choice A:True.
Choice B:False.
Question 3: Use of imaging techniques on animals is completely non-invasive, and hence there are no major welfare issues involved. T/F?
Reference:P. Workman, E. O. Aboagye, F. Balkwill, et al., " Guidelines for the welfare and use of animals in cancer research," Br J Cancer 102, 1555-1577 (2010).
Choice A:True.
Choice B:False.
Question 4: All of the following are true except:
Reference:M. Paoloni, C. Khanna, "Translation of new cancer treatments from pet dogs to humans," Nat Rev Cancer 8, 147-156 (2008). 1 M. Paoloni, C. Khanna, "Translation of new cancer treatments from pet dogs to humans," Nat Rev Cancer 8, 147-156 (2008).
Choice A:Inclusion of dogs from different breeds in clinical trials provides a cross-sectional value that is often higher than that obtained in studies of laboratory animals by providing a background genetic diversity similar to that seen in human populations.
Choice B:The most common cancers of humans, including breast, prostate, gastrointestinal, and lung carcinomas, are also common in dogs.
Choice C:Novel agents not yet submitted for IND may be treated similarly to other preclinical studies in traditional model species.
Choice D:An important attribute of cancer studies in dogs is the opportunity to perform serial interventions (e.g., biopsies and imaging) for the same subject.
Question 5: Which clinical change during treatment can be flagged using an EPID in-vivo dosimetry approach?
Reference:Mijnheer, Ben J., et al. "Overview of 3-year experience with large-scale electronic portal imaging device–based 3-dimensional transit dosimetry." Practical radiation oncology 5.6 (2015): e679-e687.
Choice A:Anatomy change.
Choice B:Patient positioning.
Choice C:Bolus material placement.
Choice D:All of the above.
Question 6: Which parameter has been shown to be most sensitive to small spatial shifts during cranial IMRT delivery?
Reference:Hsieh, Emmelyn S., et al. "Can a commercially available EPID dosimetry system detect small daily patient setup errors for cranial IMRT/SRS?." Practical Radiation Oncology (2016).
Choice A:Gamma.
Choice B:Distance-to-agreement (DTA).
Choice C:% dose difference.
Choice D:Difference –to-DTA.
Choice E:Gradient Compensation.
Back to session list