2017 AAPM Annual Meeting
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Session Title: Optical Image-guided Surgery
Question 1: The only feature available in FDA cleared fluorescence imaging systems today is:
Reference:DSouza AV, Lin H, Henderson ER, Samkoe KS, Pogue BW. “Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging” J Biomed Opt. 2016 Aug 1;21(8):80901.
Choice A:Operation under any lighting conditions.
Choice B:PicoMolar sensitivity to the probe concentration.
Choice C:Molecular binding and uptake.
Choice D:Perfusion imaging.
Question 2: The key limitation in targeted fluorescence imaging for cancer tumor margin detection is:
Reference:Pogue BW, Paulsen KD, Samkoe KS, Elliott JT, Hasan T, Strong TV, Draney DR, Feldwisch J. “Vision 20/20: Molecular-guided surgical oncology based upon tumor metabolism or immunologic phenotype: Technological pathways for point of care imaging and intervention” Med Phys. 2016 Jun;43(6):3143.
Choice A:Background signal from normal tissue.
Choice B:Confounding light signals in the room.
Choice C:Enhanced permeability and retention.
Choice D:The tumor type.
Question 3: The main disadvantage of confocal microscopy for intraoperative imaging is:
Reference:Abeytunge S, Li Y, Larson B, Toledo-Crow R, Rajadhyaksha M. Rapid confocal imaging of large areas of excised tissue with strip mosaicing. Journal of Biomedical Optics. 2011;16(5):050504. doi:10.1117/1.3582335.
Choice A:Signal to noise ratio.
Choice B:Contrast.
Choice C:Resolution.
Choice D:Speed.
Question 4: Unlike conventional microscopy methods, light-sheet microscopy utilizes:
Reference:Santi PA. Light Sheet Fluorescence Microscopy: A Review. Journal of Histochemistry and Cytochemistry. 2011;59(2):129-138. doi:10.1369/0022155410394857.
Choice A:Pulsed lasers.
Choice B:Separate illumination and collection paths oriented at 90 degrees.
Choice C:Ultraviolet excitation light.
Choice D:Photomultiplier tubes for fluorescence detection.
Question 5: All of the following are advantages of using near-infrared fluorescence imaging except:
Reference:Visgauss J, Eward W, Brigman B. Innovations in Intraoperative Tumor Visualization. Orthop Clin N Am. 2016; 47: 253–264.
Choice A:Greater depth of field.
Choice B:Decreased autofluorescence for reduction of background noise.
Choice C:Increased absorption by hemoglobin and lipids which improve optimal surgical use.
Choice D:Enhanced tissue penetration and decreased scattering.
Question 6: Unlike optical imaging, optoacoustic imaging:
Reference:de Boer E, Harlaar N, Taruttis A, Nagengast W, Rosenthal E, Ntziachristos V, van Dam G. Optical innovations in surgery. British Journal of Surgery. 2015; 102: e56–e72.
Choice A:Offers high resolution at depths of up to a few centimeters.
Choice B:Detects optical absorption by means of a charge-coupled device camera.
Choice C:Demonstrates decreased absorption by hemoglobin.
Choice D:Does not permit detection of melanin.
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