2019 AAPM Annual Meeting
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Session Title: Focused Ultrasound in Radiation Oncology
Question 1: Which of the following statements is true?
Reference:Zhu, Lifei, Michael B. Altman, Andrei Laszlo, William Straube, Imran Zoberi, Dennis E. Hallahan, and Hong Chen. "Ultrasound Hyperthermia Technology for Radiosensitization." Ultrasound in medicine & biology (2019).
Choice A:Hyperthermia is a new treatment technique which does not appear to offers any therapeutic benefit when added to a treatment course for Radiation Therapy
Choice B:Multiple studies have shown that ultrasound can be used for hyperthermia treatments in many treatment sites
Choice C:Use of MRI with ultrasound-mediated hyperthermia offers no benefit compared to other forms of temperature monitoring
Choice D:MRI is the only available form of hyperthermia temperature monitoring
Question 2: Which of the following are limitations of current commercial MR-guided HIFU systems when used for hyperthermia treatments?
Reference:Reference: Shim, Jenny, Robert M. Staruch, Korgun Koral, Xian‐Jin Xie, Rajiv Chopra, and Theodore W. Laetsch. "Pediatric Sarcomas Are Targetable by MR‐Guided High-Intensity Focused Ultrasound (MR‐HIFU): Anatomical Distribution and Radiological Characteristics." Pediatric blood & cancer 63, no. 10 (2016): 1753-1760
Choice A:Limited treatment depths (<10 cm from the surface)
Choice B:Targets proximal to bones can be untreatable
Choice C:Motion such as breathing or peristalsis can cause MR temperature mapping artifacts
Choice D:All of the above
Question 3: The biomechanical effects of ultrasound-stimulated microbubbles can achieve radiation enhancement. True or False
Reference:Czarnota, G. J. et al. Tumor radiation response enhancement by acoustical stimulation of the vasculature. Proc. Natl. Acad. Sci. U. S. A. 109, E2033–E2041 (2012).
Choice A:True
Choice B:False
Question 4: What are the bioeffects associated with ultrasound-stimulated microbubbles used to enhance radiation therapy?
Reference:El Kaffas, A. & Czarnota, G. J. Biomechanical effects of microbubbles: from radiosensitization to cell death. Future Oncol. 11, 1093–108 (2015).
Choice A:Augmented ceramide production
Choice B:Ceramide-induced cell death
Choice C:Rapid vascular shutdown
Choice D:All the above
Question 5: Clonogenic assays measure
Reference:A. Munshi, M. Hobbs, R. E. Meyn (2005), ‘Clonogenic Cell Survival Assay’, Chemosensitivity: vol. 1: In vitro Assays, p. 21-28,
Choice A:Cell viability
Choice B:The loss of reproductive integrity
Choice C:The fraction of necrotic cells
Choice D:Proliferation
Question 6: The thermal dose concept
Reference:S. A. Sapareto and W. C. Dewey (1984), ‘Thermal dose determination in cancer therapy’, International Journal of Radiation Oncology*Biology*Physics, vol. 10(6), p. 787-800
Choice A:Enables to express arbitrary time temperature combinations in equivalent minutes at 43C
Choice B:Provides a measure of the cells’ heat sensitivity
Choice C:Is an alternative to the linear quadratic model for hyperthermia treatments
Choice D:All of the above
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