| Question 1: Which optical therapy does not require an administered agent to work? |
| Reference: | “Fluorescence‐guided surgery and intervention — An AAPM emerging technology blue paper”, Pogue B, et al, Med. Phys. 45(6), pp. 2681-2688 (2018).
“The Yin and Yang of PDT and PTT”, Wilson BC, Weersink RA., Photochem. Photobiol. 96(2) pp 219-231 (2020). |
| Choice A: | Photodynamic therapy |
| Choice B: | Photothermal therapy |
| Choice C: | Fluorescence guided surgery |
| Question 2: Treatment response cannot be directly imaged for which phototherapy? |
| Reference: | “Fluorescence‐guided surgery and intervention — An AAPM emerging technology blue paper”, B. Pogue, et al, Med. Phys. 45(6), pp. 2681-2688 (2018).
“A Clinical Prototype Transrectal Diffuse Optical Tomography (TRDOT) System for In vivo Monitoring of Photothermal Therapy (PTT) of Focal Prostate Cancer”, He J, et al, IEEE Transactions on Biomedical Engineering, 2019, doi: 10.1109/TBME.2019.2955354. |
| Choice A: | Photodynamic Therapy |
| Choice B: | Photothermal Therapy |
| Choice C: | Fluorescence guided surgery |
| Question 3: MRI-guided HIFU neurosurgery has been performed to treat patients with: |
| Reference: | Quadri, Syed A., et al. "High-intensity focused ultrasound: past, present, and future in neurosurgery." Neurosurgical focus 44.2 (2018): E16. |
| Choice A: | Essential tremor |
| Choice B: | Chronic neuropathic pain |
| Choice C: | Tremor dominant Parkinson’s disease |
| Choice D: | Obsessive-compulsive disorder |
| Choice E: | All of the above |
| Question 4: Unless properly compensated for, skull perturbs propagation of ultrasound into the brain which can cause: |
| Reference: | Kyriakou, Adamos, et al. "A review of numerical and experimental compensation techniques for skull-induced phase aberrations in transcranial focused ultrasound." International journal of hyperthermia 30.1 (2014): 36-46. |
| Choice A: | Distortion and shift of the acoustic focus |
| Choice B: | Increase in tissue impedance |
| Choice C: | Magnetic susceptibility artifacts |
| Choice D: | Blood brain barrier opening |
| Choice E: | All of the above |
| Question 5: Target registration error is correlated with fiducial registration error. |
| Reference: | https://doi.org/10.1117/12.813601 |
| Choice A: | True |
| Choice B: | False |
| Question 6: Which of the following may be used as input for 3D-2D image registration? |
| Reference: | https://doi.org/10.1016/j.media.2010.03.005 |
| Choice A: | CT or MR image of a patient |
| Choice B: | Statistical model of anatomy |
| Choice C: | Geometric model of an implant |
| Choice D: | All of the above |
