2021 AAPM Virtual 63rd Annual Meeting
Back to session list

Session Title: Imaging Markers of Breast Cancer Risk
Question 1: What proportion of women in the United States general breast screening population have dense breasts, that is, breasts that are heterogeneously or extremely dense?
Reference:Sprague BL, Gangnon RE, Burt V, Trentham-Dietz A, Hampton JM, Wellman RD, KAerlikowske K, Miglioretti DL. Prevalence of mammographically dense breasts in the United States. J Natl Cancer Institute, 2014 Sep 12;106(10):dju255/
Choice A:10% or less
Choice B:30-50%
Choice C:60-80%
Choice D:none of the above
Question 2: Mammographic markers associated with an increased risk of breast cancer include all but one of the following:
Reference:Gastounioti A, Damases C, Scott CG, Brandt KR, Jensen MR, Hruska CB, Wu FF, Norman AD, Conant EF, Winham SJ, Kerlikowske K, Konston D, Vachon CM. Evaluation of LIBRA Software for Fully Automated Mammographic Density Assessment in Breast Cancer Risk Prediction. Radiology 2020 Jul;296(1):24-31
Choice A:BI-RADS density of c or d
Choice B:Microcalcifications
Choice C:Increased non-dense volume (NDV)
Choice D:Increased dense volume (DV)
Question 3: Most clinical breast cancer risk models now incorporate breast density or other imaging risk markers.
Reference:Louro J, Posso M, Hilton Boon M, Roman M, Domingo L, Castells X, Sala M. A systematic review and quality assessment of individualised breast cancer risk prediction models. Br J Cancer. 2019;121(1):76-85.
Choice A:True
Choice B:False
Question 4: Regarding Single Nucleotide Pleomorphisms (SNPs), which of the following is true?
Reference:Mavaddat N, et al. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. Am J Hum Genet. 2019 Jan 3;104(1):21-34. doi: 10.1016/j.ajhg.2018.11.002. Epub 2018 Dec 13. PMID: 30554720; PMCID: PMC6323553.
Choice A:SNPs are derived from genome-wide association studies (GWAS)
Choice B:Panels of SNPs can generate a polygenic risk score (PRS)
Choice C:Are common genetic variations
Choice D:All of the above
Question 5: "True or False: The phenotype, which depends on the interaction between genes and the environment, can demonstrate heterogeneity."
Reference:Keren, L., Angelo, M. Mapping cell phenotypes in breast cancer. Nat Cancer 1, 156–157 (2020). https://doi.org/10.1038/s43018-020-0031-9
Choice A:True
Choice B:False
Question 6: Artificial Intelligence applications thus far for risk assessment have demonstrated that
Reference:Yala A, Lehman C, Schuster T, Portnoi T, Barzilay R. A Deep Learning Mammography-based Model for Improved Breast Cancer Risk Prediction. Radiology. 2019 Jul;292(1):60-66. doi: 10.1148/radiol.2019182716. Epub 2019 May 7. PMID: 31063083.
Choice A:Radiologists will be replaced
Choice B:Other imaging features beyond breast density are associated with breast cancer risk.
Choice C:All breasts are alike
Choice D:There will be no role for them in the future
Back to session list