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Deformable Registration Method Using B-TPS in Radiotherapy

Y Xie

Y Xie*, Shenshen Institutes of Advanced Technology, Shenzhen, China

SU-E-J-89 Sunday 3:00:00 PM - 6:00:00 PM Room: Exhibit Hall

Purpose: A novel deformable registration method for four-dimensional computed tomography (4DCT) images is developed in radiation therapy.

Methods: The proposed method combines the thin plate spline (TPS) and B-spline together to achieve high accuracy and high efficiency. The method consists of two steps. First, TPS is used as a global registration method to deform large unfit regions in the moving image to match counterpart in the reference image. Then B-spline is used for local registration, the previous deformed moving image is further deformed to match the reference image more accurately.

Results: Two clinical CT image sets, including one pair of lung and one pair of liver, are simulated using the proposed algorithm, which results in a tremendous improvement in both run-time and registration quality, compared with the conventional methods solely using either TPS or B-spline.

Conclusions: The proposed method can combine the efficiency of TPS and the accuracy of B-spline, performing good adaptively and robust in registration of clinical 4DCT image.

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