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Application of a Combination Method of Atlas-Based and Model-Based Auto-Segmentation in Thorax-And-Abdomen Cancer

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X Jiang

XQ Jiang*, QF Jiang, T Li, JH Xiao, RM Zhong, GJ Li, S Bai, Department of Radiation Oncology, Chengdu, Sichuan

SU-E-J-101 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Atlas-based auto-segmentation and model-based auto-segmentation were combined to improve accuracy of auto-segmentation for thoraxâ‚‹andâ‚‹abdomen cancer patient,herein referred to as A&M method. The purposes of this study were to evaluation the performance of A&M method and try to establish auto-segmentation application protocol in clinical.

Two major steps were performed in A&M method. Firstly, planning images and corresponding normal organ contours from 10 thorax-and-abdomen patients were selected as atlases input for ABAS. Auto-segmentation was performed on planning images of 20 thorax-and-abdomen new patients using ABAS software. Secondly, results from ABAS were adjusted using MBS software based on characteristic values of each organ. All operations were automatic running by using pre-edited scripting programs. Physicians reviewed the final A&M results and made necessary modifications.

The Dice Similarity Coefficient (DSC), that between contours generated by A&M auto-segmentation method and modified contours, was used to evaluate accuracy of A&M auto-segmentation. It also was used to compare with the DSC between contours generated by ABAS only and physicians modified results based on A&M contours.

Compared to physicians modified results based on A&M contours, the mean DSC to right Lung, left Lung, Heart, Liver, right Kidney, left Kidney, Spleen, with respect to the A&M auto-segmentation and the ABAS auto-segmentation were 0.95 vs. 0.96 (p=0.11); 0.95 vs. 0.96 (p=0.42); 0.93 vs. 0.91 (p<0.01); 0.95 vs. 0.93 (p<0.001);and 0.93 vs. 0.88 (p<0.01);0.95 vs. 0.89 (p<0.01), 0.86 vs. 0.80 (p<0.001), respectively. Auto-segmentation of all OARs using A&M method took about 12 minutes per patient in total, including ABAS 10 minutes and MBS 2 minutes.

Our results demonstrated the AM method can significantly improve the results from ABAS only for most normal organs in thoraxâ‚‹andâ‚‹abdomen cancer patients. And the AM method is more convention and accurate than MBS method only in clinical applications.

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