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Quantitative Study of 18F-Fluorodeoxyglucose and 18F-Fluorothymidine PET Characteristics in Esophageal Squamous Cell Carcinoma Staging

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C Ma

C Ma*,

SU-E-J-116 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose: The aim of this study was to quantitatively evaluate the value of diagnostic information provided by both 18F-FDG and 18F-FLT PET and quantitatively investigated whether 18F-FLT PET had a better performance compared with 18F-FDG PET in esophageal squamous cell carcinoma (ESCC) staging and delineation.

Methods:26 patients with newly diagnosed ESCC and underwent pretreatment 18F-FDG and 18F-FLT PET were included in this study. The indices such as the standardized uptake value (SUV), gross tumor length and extracted texture parameters between 18F-FDG and 18F-FLT PET were compared, respectively. Tumor delineation length on 18F-FDG (SUV threshold 2.5) and 18F-FLT (SUV threshold 1.4) PET were validated by pathologic gross tumor length.

Results:18F-FDG highly correlated with 18F-FLT possessing a high correlation coefficient value r approximate 0.8 and p<0.001 in SUVmax or SUVmean. 18F-FDG uptake was significantly higher than 18F-FLT with respect to average SUVmax(18F-FDG: 11.48, 18F-FLT: 6.07) or average SUVmean (18F-FDG: 6.09, 18F-FLT: 3.80), with Paired T-test result p<0.001. In terms of texture parameters relationship Entropy and Correlation (two derived texture parameters) showed statistically significant difference. Both of 18F-FDG and 18F-FLT PET SUV, some of texture parameters,gross tumor length and shape feature showed statistically significant difference with respect to their feasibility in ESCC staging. The mean±standard deviation pathologic longitudinal tumor length was 5.52±2.56 cm and delineation length for 18F-FDG and 18F-FLT were 5.60±2.32 cm and 5.49±2.43 cm, respectively.

Conclusion:The 18F-FDG and 18F-FLT PET scans have their own advantages in ESCC staging and tumors were well identified as the nonphysiologic distribution of radiotracers intensity typically higher than normal tissues on either PET scans. Those different indices extracted from PET scans can be potentially employed to differentiate AJCC and TNM in ESCC stage.

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