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Program Information

Clinical Trials

Jean Moran

J Moran1*, Y Xiao2*, (1) Univ Michigan Medical Center, Ann Arbor, MI, (2) Thomas Jefferson Univ Hospital, Philadelphia, PA

TU-A-Salon EF-1 Tuesday 7:30:00 AM - 9:30:00 AM Room: Salon EF

Several studies have demonstrated the importance of quality with respect to outcomes in multi-disciplinary clinical trials. This session will present on the work of AAPM Task Group 113 with respect to improving consistency in clinical trials. Examples which have demonstrated the importance of consistency in different aspects of the radiation therapy process will be presented. The role of audits, credentialing, and benchmarks will also be discussed, with examples demonstrating important improvements in the quality of clinical trials. Then, a proposed new framework for supporting clinical trials will be described: the Clinical Trial Quality Assurance Imaging and Radiation Oncology Core Group (IROC). An important aspect of the proposed group is to acknowledge the vital role of multi-modality imaging in identifying target volumes, treatment assessment, and volumetric image guidance for advanced technology trials. Infrastructure requirements for an efficient workflow will be described along with some examples of how this infrastructure currently works. The infrastructure supports investigators leading the multi-disciplinary trials and allows them to provide timely and effective feedback to the investigators at the individual institution who are enrolling patients in clinical trials. Finally, a vision for future quality assurance needs will be presented.

Learning Objectives:
1. To report on the additional requirements for multi-disciplinary clinical trials.
2. To describe examples demonstrating how audits, credentialing, and benchmarks can support quality in clinical trials
3. To describe the benefits and requirements of close coordination of RT and imaging QA
4. To describe current and future needs for an efficient informatics infrastructure for clinical trials

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