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Measuring Prompt Gamma Emission Profiles with a Multi-Stage Compton Camera During Proton Beam Irradiaition: Initial Studies

J Polf

J Polf1*, S Brown2 , J Mann2 , D Mackin3 , Y Zheng4 , M McCleskey1 , S Beddar3 , Z He2 , (1) University of Maryland School of Medicine, Baltimore, MD,(2) University of Michigan, Ann Arbor, MI, (3) MD Anderson Cancer Center, Houston, TX, (4) Procure Proton Therapy Center, Oklahoma City, OK.


SU-E-J-121 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose: Recent studies have suggested that the characteristics of prompt gammas (PG) emitted during proton beam irradiation are advantageous for determining beam range during treatment delivery. The purpose of this work was to determine the feasibility of determining the proton beam range from PG data measured with a prototype Compton camera (CC) during proton beam irradiation.

Methods: Using a prototype multi-stage CC the PG emission from a water phantom was measured during irradiation with clinical proton therapy beams. The measured PG emission data was used to reconstruct an image of the PG emission using a backprojection reconstruction algorithm. One dimensional (1D) profiles extracted from the PG images were compared to: 1) PG emission data measured at fixed depths using collimated high purity Germanium and Lanthanum Bromide detectors, and 2) the measured depth dose profiles of the proton beams.

Results: Comparisons showed that the PG emission profiles reconstructed from CC measurements agreed very well with the measurements of PG emission as a function of depth made with the collimated detectors. The distal falloff of the measured PG profile was between 1 mm to 4 mm proximal to the distal edge of the Bragg peak for proton beam ranges from 4 cm to 16 cm in water. Doses of at least 5 Gy were needed for the CC to measure sufficient data to image the PG profile and localize the distal PG falloff.

Conclusion: Initial tests of a prototype CC for imaging PG emission during proton beam irradiation indicated that measurement and reconstruction of the PG profile was possible. However, due to limitations of the operational parameters (energy range and count rate) of the current CC prototype, doses of greater than a typical treatment dose (~2 Gy) were needed to measure adequate PG signal to reconstruct viable images.

Funding Support, Disclosures, and Conflict of Interest: funding support for this project provided by a grant from DoD.

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