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Program Information

Realization of Three-Dimensional Conformal Dose Planning in Prostate Brachytherapy

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S Jiang

Z Li1 , S Jiang*1 , Z Yang1 , H Bai2 , X Zhang2 , (1) Tianjin University, Tianjin, China (2) Seeds biological Pharmacy Ltd, Tianjin, China


SU-E-T-279 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose: Successful clinical treatment in prostate brachytherapy is largely dependent on the effectiveness of pre-surgery dose planning. Conventional dose planning method could hardly arrive at a satisfy result. In this abstract, a three-dimensional conformal localized dose planning method is put forward to ensure the accuracy and effectiveness of pre-implantation dose planning.

Methods: Using Monte Carlo method, the pre-calculated 3-D dose map for single source is obtained. As for multiple seeds dose distribution, the maps are combined linearly to acquire the 3-D distribution. The 3-D dose distribution is exhibited in the form of isodose surface together with reconstructed 3-D organs group real-timely. Then it is possible to observe the dose exposure to target volume and normal tissues intuitively, thus achieving maximum dose irradiation to treatment target and minimum healthy tissues damage. In addition, the exfoliation display of different isodose surfaces can be realized applying multi-values contour extraction algorithm based on voxels. The needles could be displayed in the system by tracking the position of the implanted seeds in real time to conduct block research in optimizing insertion trajectory.

Results: This study extends dose planning from two-dimensional to three-dimensional, realizing the three-dimensional conformal irradiation, which could eliminate the limitations of 2-D images and two-dimensional dose planning. A software platform is developed using VC++ and Visualization Toolkit (VTK) to perform dose planning. The 3-D model reconstruction time is within three seconds (on a Intel Core i5 PC). Block research could be conducted to avoid inaccurate insertion into sensitive organs or internal obstructions. Experiments on eight prostate cancer cases prove that this study could make the dose planning results more reasonable.

Conclusion: The three-dimensional conformal dose planning method could improve the rationality of dose planning by safely reducing the large target margin and avoiding dose dead zones for prostate cancer treatment.

Funding Support, Disclosures, and Conflict of Interest: 1) National Natural Science Foundation of People's Republic of China (No. 51175373). 2) New Century Educational Talents Plan of Chinese Education Ministry (NCET-10-0625). 3) Scientific and Technological Major Project, Tianjin (No. 12ZCDZSY10600).

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