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Development and Validation of Analytical Models Predicting Secondary Neutron Radiation in Proton Therapy Applications

J Farah

J Farah1*, A Bonfrate1 , A De Olivera2 , S Delacroix2 , L Donadille1 , J Herault3 , F Martinetti1 , S Piau4 , F Trompier1 , I Vabre4 , I Clairand1 , (1) IRSN, Fontenay-aux-roses, Ile-de-France, (2) Institut Curie - Centre de Protontherapie d Orsay, Orsay, ,(3) Centre Antoine Lacassagne, Nice, ,(4) Institut de Physique Nucleaire d Orsay, Orsay, ,


SU-E-T-479 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Test and validation of analytical models predicting leakage neutron exposure in passively scattered proton therapy.

Taking inspiration from the literature, this work attempts to build an analytical model predicting neutron ambient dose equivalents, H*(10), within the local 75 MeV ocular proton therapy facility. MC simulations were first used to model H*(10) in the beam axis plane while considering a closed final collimator and pristine Bragg peak delivery. Next, MC-based analytical model was tested against simulation results and experimental measurements. The model was also expended in the vertical direction to enable a full 3D mapping of H*(10) inside the treatment room. Finally, the work focused on upgrading the literature model to clinically relevant configurations considering modulated beams, open collimators, patient-induced neutron fluctuations, etc.

The MC-based analytical model efficiently reproduced simulated H*(10) values with a maximum difference below 10%. In addition, it succeeded in predicting measured H*(10) values with differences <40%. The highest differences were registered at the closest and farthest positions from isocenter where the analytical model failed to faithfully reproduce the high neutron fluence and energy variations. The differences remains however acceptable taking into account the high measurement/simulation uncertainties and the end use of this model, i.e. radiation protection. Moreover, the model was successfully (differences < 20% on simulations and < 45% on measurements) extended to predict neutrons in the vertical direction with respect to the beam line as patients are in the upright seated position during ocular treatments. Accounting for the impact of beam modulation, collimation and the present of a patient in the beam path is far more challenging and conversion coefficients are currently being defined to predict stray neutrons in clinically representative treatment configurations.

Analytical models predicting secondary neutrons in proton therapy represent a promising solution that substitute for time-consuming MC calculations.

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