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Geometric and Dosimetric Evaluation of a 4D-CBCT Reconstruction Technique Using Prior Knowledge

Y Zhang

Y Zhang*, F Yin , L Ren , Duke University Medical Center, Durham, NC


SU-D-17A-1 Sunday 2:05PM - 3:00PM Room: 17A

To evaluate a 4D-CBCT reconstruction technique both geometrically and dosimetrically

A prior-knowledge guided 4D-CBCT reconstruction method named the motion-modeling and free-form deformation (MM-FD) has been developed. MM-FD views each phase of the 4D-CBCT as a deformation of a prior CT volume. The deformation field is first solved by principal component analysis based motion modeling, followed by constrained free-form deformation.

The 4D digital extended-cardiac-torso (XCAT) phantom was used for comprehensive evaluation. Based on a simulated 4D planning CT of a lung patient, 8 different scenarios were simulated to cover the typical on-board anatomical and respiratory variations: (1) synchronized and (2) unsynchronized motion amplitude change for body and tumor; tumor (3) shrinkage and (4) expansion; tumor average position shift in (5) superior-inferior (SI) direction, (6) anterior-posterior (AP) direction and (7) SI, AP and lateral directions altogether; and (8) tumor phase shift relative to the respiratory cycle of the body. Orthogonal-view 30° projections were simulated based on the eight patient scenarios to reconstruct on-board 4D-CBCTs.

For geometric evaluation, the volume-percentage-difference (VPD) was calculated to assess the volumetric differences between the reconstructed and the ground-truth tumor.

For dosimetric evaluation, a gated treatment plan was designed for the prior 4D-CT. The dose distributions were calculated on the reconstructed 4D-CBCTs and the ground-truth images for comparison.

The MM-FD technique was compared with MM-only and FD-only techniques.

The average (±s.d.) VPD values of reconstructed tumors for MM-only, FD-only and MM-FD methods were 59.16%(± 26.66%), 75.98%(± 27.21%) and 5.22%(± 2.12%), respectively. The average min/max/mean dose (normalized to prescription) of the reconstructed tumors by MM-only, FD-only, MM-FD methods and ground-truth tumors were 78.0%/122.2%/108.2%, 13%/117.7%/86%, 58.1%/120.8%/103.6% and 57.6%/118.6%/101.8%,respectively.

The MM-FD method provides superior reconstruction accuracy both geometrically and dosimetrically, which can potentially be used for 4D target localization, dose tracking and adaptive radiation therapy.

Funding Support, Disclosures, and Conflict of Interest: This research is supported by grant from Varian Medical Systems.

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