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Effect of Number of Pinholes in Onboard Robotic Multi-Pinhole SPECT System

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M Touch

M Touch*, J Bowsher , S Yan , F Yin , Duke University Medical Center, Durham, NC


SU-E-I-79 Sunday 3:00PM - 6:00PM Room: Exhibit Hall

Purpose: To study the effect of number of pinholes for a novel Single Photon Emission Computed Tomography (SPECT) system for onboard molecular and functional imaging.

Methods: Comparison studies were performed using simulation for the 49-pinhole SPECT system and a series of reductions in number of pinholes. Trajectories about the breast of a supine patient were considered. Minimum distances, radii of rotation (RORs), were determined by requirements to fully view the region of interest (ROI) and to avoid collision between the detector and the patient. Reductions in RORs translate into improvements in sensitivity. Starting from the 49-pinhole system, pinholes were removed pod by pod. The furthest two end pods in the Sup-Inf direction were removed first for their higher likelihood of alleviating the collision avoidance criteria. After iterating through different combinations of pinhole pods, and selecting three combinations, the corresponding RORs were used to analytically calculate sensitivities.

Results: Based on the Methods procedure, 3 combination of pods removal were identified: 1) Superior peripheral pod 2) Inferior peripheral pod 3) both pods. RORs were reduced at only one multi-pinhole stop. Analytic calculation showed that sensitivities were reduced from 0.032 for the 49-pinhole system to 0.028 for 42-pinhole and to 0.023 for 39-pinhole system respectively. The sensitivity per pinhole detector was approximately the same for all three cases.

Conclusion: For the trajectories considered, only minimal improvements in RORs were identified by removing pinhole pods. Consequently, sensitivities decreased in proportion to the number of pinholes. Studies of other anatomical sites are needed to determine if in some cases sensitivity per pinhole can be improved by removing some pinholes.

Funding Support, Disclosures, and Conflict of Interest: PHS/NIH/NCI grant R21-CA156390-01A1

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