Encrypted login | home

Program Information

MR Imaging with DTI Can Predict Motor Outcome for Patients with Intracerebral Hemorrhage

no image available
R Konduru

M Kasam1 , S Konduru2 , R Konduru3*, (1) Mayo Clinic Rochester, Rochester, MN, (2) University Of MN, Rochester, MN, (3) University Of MN Rochester

PO-BPC-Exhibit Hall-16 Saturday  Room: Exhibit Hall

Purpose:Intracerebral hemorrhage (ICH) is one of the major devastating forms of stroke. This diease currently do not have viable treatment options. Diffusion tensor imaging (DTI) records fractional anisotropy, which measures the degree of directionality in the diffusion process of water using a scale from 0 to 1, where 0 is equivalent to diffusion in all directions and 1 represents diffusion in a single direction and restriction in all others. Mean diffusivity measures the amount of diffusion. Disintegration of the CST is represented by a lower FA value and higher MD value.

Methods:We have retrospectively collected multiple MRI scans of patients ( with approved IRB protocol) admitted into our hospital from the past one year and have their MRIs between week 3, 6 after the occurrence of ICH with a DTI sequence on a 3-Tesla GE scanner . We obtained FA and MD data on the cortical spinal tracts by drawing ROI on the cerebral peduncle, internal capsule, and pons of both ipsilateral and contralateral to the hematoma. The ROIs were used to calculate FA, MD, and volume. The correlation of FA, MD, and volume s were evaluated.

Results:We obtained data on 9 patients with basal ganglia hemorrhages. Preliminary analysis demonstrates that lower FA values correspond to worsening outcome and increased motor deficits. On week 3 and 6 FA of the cerebral peduncle on the affected side had direct correlation with worsening outcome and the correlation coefficients are 0.7 and 0.8 respectively. Additional data is needed to investigate further.

Conclusion:ICH is a devastating disease with no approved medical therapies. These data may be an important biomarker that allows clinicians to monitor patient recovery and provide insight on the pathophysiologic course of this disease. When the pathophysiology is better understood, potential treatment can be tailored to those patients most likely to respond.

Microsoft OLE DB Provider for ODBC Drivers error '80040e14'

[Microsoft][ODBC SQL Server Driver][SQL Server]The multi-part identifier "db2012.amos.dbo.AbstractID" could not be bound.

/meetings/2014SCM/PRAbs.asp, line 283