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Propagation of Rectum and Bladder Contours for Tandem and Ring (T&R) HDR Treatment Using Deformable Image Registration

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Y Yuan

Y Yuan*, M Chao , R Sheu , V Dumane , V Gupta , Y Lo , Mount Sinai Medical Center, New York, NY


SU-E-J-103 (Sunday, July 12, 2015) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose:To investigate the feasibility of using DIR to propagate the manually contoured rectum and bladder from the 1st insertion to the new CT images on subsequent insertions and evaluate the segmentation performance.

Methods:Ten cervical cancer patients, who were treated by T&R brachytherapy in 3-4 insertions, were retrospectively collected. In each insertion, rectum and bladder were manually delineated on the planning CT by a physicist and verified by a radiation oncologist. Using VelocityAI (Velocity Medical Solutions, Atlanta, GA), a rigid registration was firstly employed to match the bony structures between the first insertion and each of the following insertions, then a multi-pass B-spine DIR was carried out to further map the sub volume that encompasses rectum and bladder. The resultant deformation fields propagated contours, and dice similarity coefficient (DSC) was used to quantitatively evaluate the agreement between the propagated contours and the manually-delineated organs. For the 3rd insertion, we also evaluated if the segmentation performance could be improved by propagating the contours from the most recent insertion, i.e., the 2nd insertion.

Results:On average, the contour propagation took about 1 minute. The average and standard deviation of DSC over all insertions and patients was 0.67±0.10 (range: 0.44 – 0.81) for rectum, and 0.78±0.07 (range: 0.63 – 0.87) for bladder. For the 3rd insertion, propagating contours from the 2nd insertion could improve the segmentation performance in terms of DSC from 0.63±0.10 to 0.72±0.08 for rectum, and from 0.77±0.07 to 0.79±0.06 for bladder. A Wilcoxon signed rank test indicated that the improvement was statistically significant for rectum (p = 0.004).

Conclusion:The preliminary results demonstrate that deformable image registration could efficiently and accurately propagate rectum and bladder contours between CT images in different T&R brachytherapy fractions. We are incorporating the propagated contours into our learning-based method to further segment these organs.

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