Program Information
The Role of Reflectance Confocal Microscopy in the Screening of Hypo-Pigmented Mycosis Fungoides
M Gao*, H Liu , T Fan , Shandong Tumor Hospital, Jinan, Shandong
Presentations
SU-E-I-89 (Sunday, July 12, 2015) 3:00 PM - 6:00 PM Room: Exhibit Hall
Purpose: Hypopigmented mycosis fungoides (HMF) is a rare variant of cutaneous T-cell lymphoma(CTCL), and the diagnosis of HMF is often missed due to its low incidence and lack of clinical suspicion. Thus, the misdiagnosis and failure to obtain biopsies lead to a long latency period from onset of hypopigmented patches to diagnosis and treatment. In this study ,we aimed to establish a new evaluation system of psoriasis by imaging the ultrastructures of the lesions with reflectance confocal microscopy(RCM) .
Methods: We used the RCM to screen the hypopigmented lesions, and those lesions were biopsied and analyzed if there was some specific findings in the RCM images. In 2014,we performed RCM imaging of 150 cases with hypopigmented lesions and 15 cases of which were confirmed with histological analysis.
Results:Based on the RCM findings,there was no significant melanin and melanocytes changes in the hypopigmented - to- achromic lesions, or sometimes even with a vitiligo-like aspect, compared with the peri-lesional normal skin, and mononuclear inflammatory cells in the epidermis and upper dermis is the most valuable clue for the suspicious of MF. Then the histology analysis confirmed the diagnosis of HMF. Those 15 cases suspicious of MF under RCM image were all diagnosed as MF by histological analysis.
Conclusions:The RCM findings correlated well with the histology results in the screening of HMF, which provides an important tool in the evaluation of HMF.
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