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BEST IN PHYSICS (THERAPY): Cherenkov Emission Dosimetry: Feasibility for Electron Radiotherapy

Y Zlateva

Y Zlateva*, I El Naqa , McGill University, Montreal, QC


MO-FG-303-2 (Monday, July 13, 2015) 4:30 PM - 6:00 PM Room: 303

Purpose: To investigate from first principles, corroborated by Monte Carlo simulations and experimental measurements, the feasibility of developing a relative Cherenkov emission (CE) dosimetry protocol for electron beam radiotherapy.

Methods: Monte Carlo (MC) simulations of mono-energetic electrons incident on water were carried out in Geant4. Percent depth Cherenkov emission (PDCE) and dose (PDD) distributions were scored for incidence energies of 4, 6, 9, 12, 15, and 18 MeV. PDCE-to-PDD analytical conversion models were developed from least-squares data fits generated for PDD as a function of PDCE at the same depth and at different depths. Experimental techniques for validation of these models are examined.

Results: Same-depth PDD versus PDCE data fits indicate that although the relationship is linear to first order (correlation r > 0.9 for all energies), it is much more accurately approximated by separate linear and quadratic models for the build-up and drop-off regions, respectively (r > 0.999), which is theoretically underpinned. To understand the source of this relationship and its basis for developing robust conversion models, an approximate quadratic first-principles model was derived and found in agreement with MC/measured data (20% deviation at worst). Conversely, data fits of PDD versus different-depth PDCE unveiled a depth-invariant effective point of measurement of 1.5-2.1 mm downstream with 4-18 MeV incidence, respectively (r > 0.999 in the drop-off region). We present an analytical first-principles justification for this shift. This method led to errors of <1% in drop-off region PDD (<2% for PDD<20% with 4 MeV incidence) and <0.2 mm in practical range prediction.

Conclusion: We present robust quantitative prediction models, derived from first-principles and supported by simulation and measurement, for relative dose from Cherenkov emission by high-energy electrons. This constitutes a major step towards development of protocols for routine clinical quality assurance as well as real-time in vivo Cherenkov dosimetry in radiotherapy.

Funding Support, Disclosures, and Conflict of Interest: The authors acknowledge partial support by Fonds de recherche du Quebec - Nature et technologies (FRQNT), CREATE Medical Physics Research Training Network grant of the Natural Sciences and Engineering Research Council of Canada (NSERC), CREATE Integrated Sensor Systems grant of NSERC, the Canadian Institutes of Health Research (CIHR), and NSERC.

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