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Study On the Impact of Tumor Shape and Size On Drug Delivery to Pancreatic Tumors

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M Soltani

M Soltani1*, H Bazmara2 , M Sefidgar3 , R Subramaniam4 , A Rahmim5 , (1) ohns Hopkins University School of Medicine, Baltimore, Maryland, and KNT university, Tehran, Iran,(2) KNT university, Tehran, Iran (3) IKI University, Qazvin, Iran (4) Johns Hopkins University School of Medicine, Baltimore, Maryland, (5) Johns Hopkins University School of Medicine, Baltimore, Maryland


SU-D-201-4 (Sunday, July 12, 2015) 2:05 PM - 3:00 PM Room: 201

Drug delivery to solid tumors can be expressed physically using transport phenomena such as convection and diffusion for the drug of interest within extracellular matrices. We aimed to carefully model these phenomena, and to investigate the effect of tumor shape and size on drug delivery to solid tumors in the pancreas.

In this study, multiple tumor geometries as obtained from clinical PET/CT images were considered. An advanced numerical method was used to simultaneously solve fluid flow and solute transport equations. Data from n=45 pancreatic cancer patients with non-resectable locoregional disease were analyzed, and geometrical information from the tumors including size, shape, and aspect ratios were classified. To investigate effect of tumor shape, tumors with similar size but different shapes were selected and analyzed. Moreover, to investigate effect of tumor size, tumors with similar shapes but different sizes, ranging from 1 to 77 cm³, were selected and analyzed. A hypothetical tumor similar to one of the analyzed tumors, but scaled to reduce its size below 0.2 cm³, was also analyzed.

The results showed relatively similar average drug concentration profiles in tumors with different sizes. Generally, smaller tumors had higher absolute drug concentration. In the hypothetical tumor, with volume less than 0.2 cm³, the average drug concentration was 20% higher in comparison to its counterparts. For the various real tumor geometries, however, the maximum difference between average drug concentrations was 10% for the smallest and largest tumors. Moreover, the results demonstrated that for pancreatic tumors the shape is not significant. The negligible difference of drug concentration in different tumor shapes was due to the minimum effect of convection in pancreatic tumors.

In tumors with different sizes, smaller tumors have higher drug delivery; however, the impact of tumor shape in the case of pancreatic tumors is not significant.

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