Program Information
Dual-Energy Based Spectral Mammography for Characterization of Breast Lesion Composition: A Postmortem Study
N Kumar*, H Ding , H Cho , D Sennung , S Molloi , Department of radiological sciences, University of California, Irvine, CA
Presentations
SU-D-204-2 (Sunday, July 12, 2015) 2:05 PM - 3:00 PM Room: 204
Purpose:To investigate whether suspicious breast lesions can be characterized by decomposition into constituent materials using dual-energy spectral mammography.
Methods:Postmortem breasts were imaged in the mammographic energy range 26-35kVp using a silicon based spectral mammography system. Plastic water and adipose-equivalent lesion disks (0.5 cm in thickness and 2 cm in diameter) of varying densities (0-100% plastic water) were inserted into the breast tissue during imaging. Dual-energy decomposition of breast images was performed based on calibration coefficients obtained from a previous phantom study. The low- and high- energy breast images were decomposed into constituent water and adipose-equivalent thickness images with each pixel value indicating the actual thickness of the constituent basis material. The thickness of water and adipose in the lesion disks were then calculated by choosing circular, concentric ROIs within and around the disks. The resulting water densities in the lesion disks were estimated and compared with the known densities of the disks.
Results:The measured (DM) and known (DK) water density measurements of the lesions were related as DM = 1.12DK + 0.02 with r2=0.98. A root-mean-square (RMS) error of 9% was calculated.
Conclusion:The results indicate that dual-energy spectral mammography can be used to quantify the composition of breast lesions, which may improve the predictive power for malignant lesions in screening mammography.
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