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MR-Guided Focused Ultrasound Therapy in Oncology

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P Ghanouni
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C Moonen

P Ghanouni1*, C Moonen2*, (1) Stanford University, Stanford, CA, (2) UMC Utrecht, Netherlands


TU-B-210-0 (Tuesday, July 14, 2015) 8:30 AM - 9:30 AM Room: 210

MR guided focused ultrasound (MRgFUS), or alternatively high-intensity focused ultrasound (MRgHIFU), is approved for thermal ablative treatment of uterine fibroids and pain palliation in bone metastases. Ablation of malignant tumors is under active investigation in sites such as breast, prostate, brain, liver, kidney, pancreas, and soft tissue. Hyperthermia therapy with MRgFUS is also feasible, and may be used in conjunction with radiotherapy and for local targeted drug delivery. MRI allows in situ target definition and provides continuous temperature monitoring and subsequent thermal dose mapping during HIFU. Although MRgHIFU can be very precise, treatment of mobile organs is challenging and advanced techniques are required because of artifacts in MR temperature mapping, the need for intercostal firing, and need for gated HIFU or tracking of the lesion in real time. The first invited talk, “MR guided Focused Ultrasound Treatment of Tumors in Bone and Soft Tissue”, will summarize the treatment protocol and review results from treatment of bone tumors. In addition, efforts to extend this technology to treat both benign and malignant soft tissue tumors of the extremities will be presented. The second invited talk, “MRI guided High Intensity Focused Ultrasound – Advanced Approaches for Ablation and Hyperthermia”, will provide an overview of techniques that are in or near clinical trials for thermal ablation and hyperthermia, with an emphasis of applications in abdominal organs and breast, including methods for MRTI and tracking targets in moving organs.

Learning Objectives:
1. Learn background on devices and techniques for MR guided HIFU for cancer therapy
2. Understand issues and current status of clinical MRg HIFU
3. Understand strategies for compensating for organ movement during MRgHIFU
3. Understand strategies for strategies for delivering hyperthermia with MRgHIFU

Funding Support, Disclosures, and Conflict of Interest: CM - research collaboration with Philips

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