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Feasibility Study of Tumor Monitoring Technique Using Prompt Gamma Rays During Antiproton Therapy

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H Shin

H Shin*, D Yoon , J Jung , M Kim , T Suh , The catholic university of Korea, Seoul, N/A


SU-G-JeP4-15 (Sunday, July 31, 2016) 5:30 PM - 6:00 PM Room: ePoster Theater

Purpose: The purpose of this study is to suggest a tumor monitoring technique using prompt gamma rays emitted during the reaction between an antiproton and a boron particle, and to verify the increase of the therapeutic effectiveness of the antiproton boron fusion therapy using Monte Carlo simulation code.

Methods: We acquired the percentage depth dose of the antiproton beam from a water phantom with and without three boron uptake regions (region A, B, and C) using F6 tally of MCNPX. The tomographic image was reconstructed using prompt gamma ray events from the reaction between the antiproton and boron during the treatment from 32 projections (reconstruction algorithm: MLEM). For the image reconstruction, we were performed using a 80 x 80 pixel matrix with a pixel size of 5 mm. The energy window was set as a 10 % energy window.

The prompt gamma ray peak for imaging was observed at 719 keV in the energy spectrum using the F8 tally fuction (energy deposition tally) of the MCNPX code.
The tomographic image shows that the boron uptake regions were successfully identified from the simulation results. In terms of the receiver operating characteristic curve analysis, the area under the curve values were 0.647 (region A), 0.679 (region B), and 0.632 (region C).
The SNR values increased as the tumor diameter increased. The CNR indicated the relative signal intensity within different regions. The CNR values also increased as the different of BURs diamter increased.

Conclusion: We confirmed the feasibility of tumor monitoring during the antiproton therapy as well as the superior therapeutic effect of the antiproton boron fusion therapy. This result can be beneficial for the development of a more accurate particle therapy.

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