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Investigation of Longitudinal Salivary Gland DCE-MRI Changes

R Ger

R Ger1,2*, M Awan3,4 , A Mohamed1,5 , Y Ding1 , S Frank1 , R Howell1,2 , H Li1,2 , H Liu1,2 , R Mohan1,2 , D Schellingerhout1 , R Stafford1,2 , J Wang1,2 , C Fuller1,2 , L Court1,2 , (1) The University of Texas M.D. Anderson Cancer Center, Houston, TX, (2) The University of Texas Graduate School of Biomedical Sciences, Houston, TX, (3) Case Western Reserve University, Cleveland, OH, (4) University Hospitals, Cleveland, OH, (5) The University of Alexandria, Alexandria, EG


WE-FG-202-12 (Wednesday, August 3, 2016) 1:45 PM - 3:45 PM Room: 202

Purpose: To determine the correlation between dose and changes through treatment in dynamic contrast enhanced (DCE) MRI voxel parameters (Ktrans, kep, Ve, and Vp) within salivary glands of head and neck oropharyngeal squamous cell carcinoma (HNSCC) patients.

Methods: 17 HNSCC patients treated with definitive radiation therapy completed DCE-MRI scans on a 3T scanner at pre-treatment, mid-treatment, and post-treatment time points. Mid-treatment and post-treatment DCE images were deformably registered to pre-treatment DCE images (Velocity software package). Pharmacokinetic analysis of the DCE images used a modified Tofts model to produce parameter maps with an arterial input function selected from each patient’s perivertebral space on the image (NordicICE software package). In-house software was developed for voxel-by-voxel longitudinal analysis of the salivary glands within the registered images. The planning CT was rigidly registered to the pre-treatment DCE image to obtain dose values in each voxel. Voxels within the lower and upper dose quartiles for each gland were averaged for each patient, then an average of the patients’ means for the two quartiles were compared. Dose-relationships were also assessed by Spearman correlations between dose and voxel parameter changes for each patient’s gland.

Results: Changes in parameters’ means between time points were observed, but inter-patient variability was high. Ve of the parotid was the only parameter that had a consistently significant longitudinal difference between dose quartiles. The highest Spearman correlation was Vp of the sublingual gland for the change in the pre-treatment to mid-treatment values with only a ρ=0.29.

Conclusion: In this preliminary study, there was large inter-patient variability in the changes of DCE voxel parameters with no clear relationship with dose. Additional patients may reduce the uncertainties and allow for the determination of the existence of parameter and dose relationships.

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