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The Impact of Treatment Planning Methods On RapidPlan Modeling for Rectum Cancer

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S Lu

S Lu*, J Peng , K Li , J Wang , W Hu , Fudan University Shanghai Cancer Center, Shanghai, Shanghai


SU-F-T-447 (Sunday, July 31, 2016) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose:To investigate the dose volume histogram (DVH) prediction varieties based on intensity modulate radiotherapy (IMRT) plan or volume arc modulate radiotherapy (VMAT) plan models on the RapidPlan.

Methods:Two DVH prediction models were generated in this study, including an IMRT model trained from 83 IMRT rectum plans and a VMAT model trained from 60 VMAT rectum plans. In the internal validation, 20 plans from each training database were selected to verify the clinical feasibility of the model. Then, 10 IMRT plans (PIMRT_by_IMRT_model) generated from IMRT model and 10 IMRT plans generated from VMAT model (PIMRT_by_VMAT_model) were compared on the dose to organs at risk (OAR), which included bladder, left and right femoral heads. The similar comparison was also performed on the VMAT plans generated from IMRT model (PVMAT_by_IMRT_model) and VMAT plans generated from VMAT (PVMAT_by_VMAT_model) model.

Results:For the internal validation, all plans from IMRT or VMAT model shows significantly improvement on OAR sparing compared with the corresponded clinical ones. Compared to the PIMRT_by_VMAT_model, the PIMRT_by_IMRT_model has a reduction of 6.90±3.87%(p<0.001) on V40 , 6.63±3.62%(p<0.001) on V45 and 4.74±2.26%(p<0.001) on V50 in bladder; and a mean dose reduction of 2.12±1.75Gy(p=0.004) and 2.84±1.53Gy(p<0.001) in right and left femoral head, respectively. There was no significant difference on OAR sparing between PVMAT_by_IMRT_model and PVMAT_by_VMAT_model.

Conclusion:The IMRT model for the rectal cancer in the RapidPlan can be applied to for VMAT planning. However, the VMAT model is not suggested to use in the IMRT planning. Cautions should be taken that the planning model based on some technique may not feasible to other planning techniques.

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