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Program Information

Establishing a Workflow for IMRT Pre-Treatment Reviews for NRG-GY006 Clinical Trial

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T Giaddui

T Giaddui1*, N Li2 , K Curry3, K Moore2 , L Mell2 , C Leath4 , C Kunos5 , Y Xiao6 , (1) Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, (2) University of California, San Diego, San Diego, CA,(3) MIM Software, Inc., Clevealand, OH,(4) University of Alabama at Birmingham, Birmingham, AL, (5) Northeastern Ohio University College, Clevealand, OH, (6) University of Pennsylvania, Philadelphia, PA.


SU-F-T-351 (Sunday, July 31, 2016) 3:00 PM - 6:00 PM Room: Exhibit Hall

To establish a workflow for NRG-GY006 IMRT pre-treatment reviews,incorporating advanced radiotherapy technologies being evaluated as part of the clinical trial.

Pre-Treatment reviews are required for every IMRT case as part of NRG-GY006 (a randomized phase II trial of radiation therapy and cisplatin alone or in combination with intravenous triapine in women with newly diagnosed bulky stage I B2, stage II, IIIB, or IVA cancer of the uterine cervix or stage II-IVA vaginal cancer. The pre-treatment review process includes structures review and generating an active bone marrow(ABM)- to be used as an avoidance structure during IMRT optimization- and evaluating initial IMRT plan quality using knowledge-engineering based planning (KBP). Institutions will initially submit their simulation CT scan, structures file and PET/CT to IROC QA center for generating ABM. The ABM will be returned to the institution for use in planning. Institutions will then submit an initial IMRT plan for review and will receive information back following implementation of a KBP algorithm, for use in re-optimization, before submitting the final IMRT used for treatment.

ABM structure is generated using MIM vista software (Version 6.5, MIM corporation, Inc.). Here, the planning CT and the diagnostic PET/CT are fused and a sub threshold structure is auto segmented above the mean value of the SUV of the bone marrow. The generated ABM were compared with those generated with other software system (e.g. Velocity, Varian) and Dice coefficient (reflects the overlap of structures) ranged between 80 – 90% was achieved. A KBP model was built in Varian Eclipse TPS using the RapidPlan KBP software to perform plan quality assurance.

The workflow for IMRT pretreatment reviews has been established. It represents a major improvement of NRG Oncology clinical trial quality assurance and incorporates the latest radiotherapy technologies as part of NCI clinical trials.

Funding Support, Disclosures, and Conflict of Interest: This project was supported by grants U24CA180803 (IROC), UG1CA189867 (NCORP), U10CA180868 (NRG Oncology Operations), U10CA180822 (NRG Oncology SDMC) from the National Cancer Institute (NCI) and PA CURE grant

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