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Pilot Study of Online Treatment Evaluation and Adaptive Re-Planning for Laryngeal SBRT

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W Mao

W Mao1, 2*, C Liu2 , H Zhong2 , T Rozario1 , W Lu1 , X Gu1 , Y Yan1 , X Jia1 , B Sumer1 , D Schwartz1 , (1) The University of Texas Southwestern Medical Ctr, Dallas, TX,(2) Henry Ford Health System, Detroit, MI


SU-C-202-5 (Sunday, July 31, 2016) 1:00 PM - 1:55 PM Room: 202

We have instigated a phase I trial of 5-fraction stereotactic body radiotherapy (SBRT) for advanced-stage laryngeal cancer. We conducted this pilot dosimetric study to confirm the potential utility of online adaptive re-planning to preserve treatment quality.

Ten cases of larynx cancer were evaluated. Baseline and daily SBRT treatment plans were generated per trial protocol. Daily volumetric images were acquired prior to every fraction of treatment. Reference simulation CT images were deformably registered to daily volumetric images using Eclipse. Planning contours were then deformably propagated to daily images. Reference SBRT plans were directly copied to calculate delivered dose distributions on deformed reference CT images. In-house software platform has been developed to calculate cumulative dose over a course of treatment in four steps: 1) deforming delivered dose grid to reference CT images using deformation information exported from Eclipse; 2) generating tetrahedrons using deformed dose grid as vertices; 3) resampling dose to a high resolution within every tetrahedron; 4) calculating dose-volume histograms. Our in-house software was benchmarked with a commercial software, Mirada.

In all ten cases including 49 fractions of treatments, delivered daily doses were completely evaluated and treatment could be re-planned within 10 minutes. Prescription dose coverage of PTV was less than intended in 53% of fractions of treatment (mean: 94%, range: 84%-98%) while minimum coverage of CTV and GTV was 94% and 97%, respectively. Maximum bystander point dose limits to arytenoids, parotids, and spinal cord remained respected in all cases, although variances in carotid artery doses were observed in a minority of cases.

Although GTV and CTV coverage is preserved by in-room 3D image guidance of larynx SBRT, PTV coverage can vary significantly from intended plans. Online adaptive treatment evaluation and re-planning is potentially necessary and our procedure is clinically applicable to fully preserve treatment quality.

Funding Support, Disclosures, and Conflict of Interest: This project is supported by CPRIT Individual Investigator Research Award RP150386.

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