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Association of Prostate Volumes with Restricted Diffusion and Prostate Cancer Aggressiveness

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Y Tschudi

Y Tschudi1*, (1) University of Miami, Miami, Florida


WE-FG-206-9 (Wednesday, August 3, 2016) 1:45 PM - 3:45 PM Room: 206

Purpose: To create an automatic workflow for evaluation of thresholds of restricted diffusion, based on Apparent Diffusion Coefficient (ADC) values in multiparametric (mp)MRI of the prostate. To investigate the association of these volumes with biopsy Gleason Score (GS).

Methods: Patients with prostate cancer, imaged on 3T Discovery MR750 (GE, Waukesha, WI) magnet were selected from departmental database based on the presence of mpMRI exam. All subsequent analyses were performed using Java plugins in MIM (MIM, Cleveland, Ohio). Prostate, peripheral zone (PZ) and urethra were contoured manually for each patient. The procedure defines three volumes on ADC in PZ, related to high (
Results: mpMRIs from 139 selected patients with mpMRI acquired between May, 2012 and February, 2016, were analyzed. Six values for T1 were investigated starting from 750 to 950 μm2/s with step of 50 μm2/s. All correlations between ADC volumes and ADC/Prostate volumes and GS were significant. The following thresholds for PZ/TZ: 950/700, 1100/900 and 1200/1100 performed the best for high, mid and low risk. The correlation coefficients of of ADC high and ADC high/Prostate were 0.45 and 0.469 with p-values <<0.00001.

Conclusion: To the best of our knowledge, this is the first report which associates volumes of low diffusion and GS.

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