Program Information
Optimization of Rotational Arc Station Parameter Optimized Radiation Therapy
P Dong1*, B Ungun1,2 , S Boyd2 , L Xing1 , (1) Stanford University School of Medicine, Stanford, CA, (2) Stanford University School of Engineering, Stanford, CA
Presentations
WE-AB-209-9 (Wednesday, August 3, 2016) 7:30 AM - 9:30 AM Room: 209
Purpose:To develop a fast optimization method for station parameter optimized radiation therapy (SPORT) and show that SPORT is capable of improving VMAT in both plan quality and delivery efficiency.
Methods:The angular space from 0° to 360° was divided into 180 station points (SPs). A candidate aperture was assigned to each of the SPs based on the calculation results using a column generation algorithm. The weights of the apertures were then obtained by optimizing the objective function using a state-of-the-art GPU based Proximal Operator Graph Solver (POGS) within seconds. Apertures with zero or low weight were thrown out. To avoid being trapped in a local minimum, a stochastic gradient descent method was employed which also greatly increased the convergence rate of the objective function. The above procedure repeated until the plan could not be improved any further. A weighting factor associated with the total plan MU also indirectly controlled the complexities of aperture shapes. The number of apertures for VMAT and SPORT was confined to 180. The SPORT allowed the coexistence of multiple apertures in a single SP. The optimization technique was assessed by using three clinical cases (prostate, H&N and brain).
Results:Marked dosimetric quality improvement was demonstrated in the SPORT plans for all three studied cases. Prostate case: the volume of the 50% prescription dose was decreased by 22% for the rectum. H&N case: SPORT improved the mean dose for the left and right parotids by 15% each. Brain case: the doses to the eyes, chiasm and inner ears were all improved. SPORT shortened the treatment time by ~1 min for the prostate case, ~0.5 min for brain case, and ~0.2 min for the H&N case.
Conclusion:The superior dosimetric quality and delivery efficiency presented here indicates that SPORT is an intriguing alternative treatment modality.
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