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Considerations About Dose Protraction Factor in TCP Calculations for Prostate VMAT Treatments

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F Clemente

F Clemente*, C Perez-Vara , M Clavo Herranz , Hospital Central de la Defensa "Gomez Ulla", Madrid, madrid


SU-F-T-686 (Sunday, July 31, 2016) 3:00 PM - 6:00 PM Room: Exhibit Hall

Dose protraction factor should be considered in order to model the TCP calculations. Nevertheless, this study describes a brief discussion showing that the lack of its inclusion should not invalidate these calculations for prostate VMAT treatments.

Dose protraction factor (G) modifies the quadratic term of the linear-quadratic expression in order to take into account the sublethal damage repair of protracting the dose delivery. If the delivery takes a short time (instantaneous), G = 1. For any other dose delivery pattern, G < 1. The Lea-Catcheside dose protraction factor for external beam radiotherapy contains terms depending of on the tissue specific repair parameter (λ) and the irradiation time (T). Expanding the exponential term using a Taylor’s series and neglecting terms of order (λT)³, the approximation leads to G = 1. The described situation occurs for 3DCRT techniques, where treatment times are about few minutes. For IMRT techniques, fraction times are prolonged compared to 3DCRT times. Wang et al. (2003) and Fowler et al. (2004) investigated the protraction effect with respect to IMRT treatments, reporting clinically significant loss in biological effect associated with IMRT delivery times.

Treatment times are noticeably reduced for prostate treatments using VMAT techniques. These times are comparable to 3DCRT times, leading to consider the previous approximation.

Dose protraction factor can be approximated by G = 1 in TCP calculations for prostate treatments using VMAT techniques.

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