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Female Pelvic Synthetic CT Generation Based On Joint Shape and Intensity Analysis

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L Liu

L Liu*, S Jolly , Y Cao , K Vineberg , J Fessler , J Balter , University Michigan, Ann Arbor, MI


SU-D-207A-1 (Sunday, July 31, 2016) 2:05 PM - 3:00 PM Room: 207A

Purpose:To develop a method for generating female pelvic synthetic CT (MRCT) images from a single MR scan and evaluate its utility in radiotherapy.

Methods:Under IRB-approval, an imaging sequence (T1_VIBE_Dixon) was acquired for 10 patients. This sequence yields 3 useful image volumes of different contrast (“in-phase” T1-weighted, fat and water). A previously published pelvic bone shape model was used to generate a rough bone mask for each patient. A modified fuzzy c-means classification was performed on the multi spectral MR data, with a regularization term that utilizes the prior knowledge provided by the bone mask and addresses the intensity overlap between different tissue types. A weighted sum of classification probabilities with attenuation values yielded MRCT volumes. The mean absolute error (MAE) between MRCT and real CT on various regions was calculated following deformable alignment (Velocity). Intensity modulated Treatment plans based on actual CT and MRCT were made and compared.

Results:The average/standard deviation of MAE across 10 patients was 10.1/6.7 HU for muscle, 6.7/4.6 HU for fat, 136.9/53.5 HU for bony tissues under 850 HU (97% of total bone volume), 188.9/119.3 HU for bony tissues above 850 HU and 17.3/13.3 HU for intra-pelvic soft tissues. Calculated doses were comparable for plans generated on CT and calculated using MRCT densities or vice versa, with differences in PTV D99% (mean/σ) of (-0.1/0.2 Gy) and (0.3/0.2 Gy), PTV D0.5cc of (-0.3/0.2 Gy) and (-0.4/1.7 Gy). OAR differences were similarly small for comparable structures, with differences in bowel V50Gy of (-0.3/0.2%) and (0.0/0.2%), femur V30Gy of (0.7/1.2%) and (0.2/1.2%), sacrum V20GY of (0.0/0.1%) and (-0.1/1.1%) and mean pelvic V20Gy of (0.0/0.1%) and (0.6/1.8%).

Conclusion: MRCT based on a single imaging sequence in the female pelvis is feasible, with acceptably small variations in attenuation estimates and calculated doses to target and critical organs.

Funding Support, Disclosures, and Conflict of Interest: Work supported by NIHR01EB016079

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