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Delivered Activity Accuracy of Radium 223 Dichloride Injections, When Being Administrated for Castration Resistant Prostate Cancer, Symptomatic Bone Metastases. The Impact of Residual Activity in the Spent Syringe and Dispensing Accuracy of Ra 223

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G Jennings

G Jennings*, Marsden Medical Physics Associates, Denville, NJ


SU-F-T-57 (Sunday, July 31, 2016) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose:To quantify the delivered activity accuracy of Radium 223 dichloride injections, when being administrated for castration – resistant prostate cancer, symptomatic bone metastases. The impact of residual activity in the spent syringe and dispensing accuracy of Ra 223.

Methods:The administration is by slow intravenous injection over 1 minute followed by double flushing of the 10 mL syringe and IV with saline. Eighty (80) procedures was used to investigate variations in the activity from the amount prescribed (μCi) = 1.35 x Patient weight Kg. The Activity dispensed into a 10mL syringe using a NIST traceable Capintec CRC-25R Chamber and a cross calibrated capintec CRC-15R , to measure activity in the syringe immediately before and after administration

Results:: The patients weight range from 121Ib to 235lb and doses ranging 74.25 μCi to 144.2 μCi. The deviation of dispensed dose vs Prescribed dose average +2.1% with a range of -1.1% to +5.7%. The Dose measured before administration ranges 79.3 μCi to 154.9 μCi. Deviation from the dispensed dose was show to average +2.9% with a range of -0.8% to +7.3%. The average residual dose post injection was 2.5 μCi or 2.2% of the pre injection activity. Ranging from 0.9 μCi to 6.2 μCi, 0.7% to 5.4% respectively. Subtracting the residual activity from that measured activity before injection and comparing it to prescription dose was shown to have an average variation of +2.7% with a range of -0.8% to 7.4%.

Conclusion:The case resulted in the 6.2 μCi maximum residual dose had two syringes. A small, 82.8 μCi activity, case resulted in the 7.4% maximum variation in measures less residual verses prescription dose. The average +2.1 % dispenses activity of Ra 223 over the prescription dosage was seen to counteract the average 2.2% residual dosage found to remain in the syringe

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