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An Alternative Patient Alignment Tool On TomoTherapy: The First In-Human Megavoltage-Topogram Acquisition

L Yang

L Yang*, D Low , P Lee , D Ruan , R Chin , T Kaprealian , M Kamrava , P Kupelian , P Beron , M Steinberg , A Chen , N Agazaryan , S Ray , X Qi , UCLA, Los Angeles, CA


SU-F-J-181 (Sunday, July 31, 2016) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose: To show the first in-human Megavoltage (MV)-Topogram acquisition for the evaluation of the potential for MV-Topogram-based alignment as an alternative to MVCT for reducing dose and imaging time.

Methods: A lung cancer patient was enrolled in an ongoing IRB-approved clinical trial at our institute. The patient was set up using the clinical protocol employing positioning lasers. 3.2mm diameter tungsten spheres were placed on the patient’s skin at their alignment tattoos to check surface-based marker concordance between topograms and MVCT. Anterior-Posterior (AP) and lateral (LAT) MV-Topograms were acquired using gantry angles of 0°/90° with a 1mm collimator opening, all MLC leafs open, 4cm/s couch speed, and 12.5s scanning time. The topogram acquisition was immediately followed by the normal MVCT scan acquisition.

MV-Topograms were reconstructed from the detector exit-data using in-house developed software. The topograms were also enhanced using contrast-limited adaptive histogram equalization (CLAHE). The MV-Topograms were registered to reference kV-based digitally reconstructed topograms. The localization results were compared against results obtained comparing the clinical MVCT to the kVCT simulation.

Results: The shifts using the unenhanced Topograms, enhanced Topograms, and MVCT were (LAT, LONG, VERT, ROLL) (5.8mm, 2.6mm, -5.6mm, 0.34°), (3.9mm, 2.5mm, -2.2mm, 0.65°) and (2.4mm, 1.5mm, -3.0mm, 0.5°), respectively. The magnitude alignment differences between the enhanced Topograms and MVCT were within 1.5 mm and 0.15°. The average MVCT and total Topogram acquisition times were 272.9s ± 31.5s and 46s, respectively.

Conclusion: MV-Topograms have the potential for providing equivalent performance with less dose and acquisition time than the traditional MVCT technique. We are evaluating other sites as well as adding patients to develop statistically significant analyses regarding the alignment quality differences. MV-Topograms are likely to be most clinically useful for bony anatomy and radiopaque marker-based alignments.

Funding Support, Disclosures, and Conflict of Interest: The study was supported by an Accuray Grant.

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