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Peripheral Dose Evaluation to the Thyroid and Contralateral Breast From Accuboost Treatments

M Talmadge

M Talmadge*, P Halvorsen , I Iftimia , Lahey Clinic, Burlington, MA


PO-BPC-Exhibit Hall-6 (Saturday, March 5, 2016)  Room: Exhibit Hall

To estimate the potential dose to the thyroid and contralateral breast for patients undergoing boost as well as accelerated partial breast irradiation (APBI) treatments using the Accuboost (Advanced Radiation Therapy, Tyngsboro, MA) surface brachytherapy system.

Peripheral measurements were made using Optically Stimulated Luminescent Dosimeters (OSLD) (Landauer Inc., Glenwood, IL) with phantoms simulating patient anatomy under varying clinical set ups.

Recognizing that variability in both patient anatomy and treatment setup would have a significant effect on the dose to these peripheral structures, a series of measurements and analysis was performed to determine an approximate range of the potential cumulative dose to the thyroid and contralateral breast for a hypothetical patient undergoing either treatment regimen taking into account the effects of the applicator type and size as well as the treatment separation distance. It was estimated that the potential dose to the thyroid ranged from 15cGy to 36cGy and from 44cGy to 109cGy for a full course of Boost and APBI treatments, respectively. For the contralateral breast, the dose was estimated to be from 38cGy to 84cGy and from 116cGy to 257cGy for Boost and APBI treatments, respectively.

These results build upon previously published peripheral measurements made using the Accuboost system┬╣, establishing an estimated range for the tissues of interest taking into consideration the effects of applicator selection and treatment separation distance. Peripheral dose, particularly to the contralateral breast, can be an important consideration for both Boost and ABPI treatments.

┬╣ Khanal SP, Ouhib Z, Benda RK, Leventouri T. Evaluation of surface dose outside the treatment area for five breast cancer irradiation modalities using thermo-luminescent dosimeters. International Journal of Cancer Therapy and Oncology. 2015; Vol 3 No 1.

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