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Monte Carlo Investigation of Dose Enhancement Due to Nanoparticles in Carbon Ion Beam Therapy

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S Ahn

S Ahn1*, K Jo2, Y Han2, H Park2, (1) Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, (2) Samsung Medical Center, Sungkyunkwan University School of Medicine Radiation Oncology, Seoul


TU-C2-GePD-T-4 (Tuesday, August 1, 2017) 10:00 AM - 10:30 AM Room: Therapy ePoster Lounge

Purpose: We investigated the dose enhancement effect due to nanoparticles in carbon ion irradiation.

Methods: For MC simulation, TOPAS version 2.0 Patch 03 was used. Firstly, carbon-12 ion scanning beams(Diameter : 1 mm) of mono-energetic 283.33 MeV/u were irradiated to a water filled phantom (30 x 30 x 30 cm³) and secondary particle information generated near the Bragg peak was recorded in a phase space file. Secondly, the obtained phase spaces file were squeeze to nanometer scale (50 nm) to irradiate Gold(Z=79), Gadolinium(Z=64), Platinum(Z=78), Zinc(Z=30) and water nano particles of 50 nm diameter located at the center of 4 x 4 x 4 μm³ water filled cube phantom. Dose enhancement ratio (DER) was computed with a 100 nm thickness of concentric shell shaped detector placed up to 1000 nm from the nano particle surface. The DER was computed at every 100 nm distance from the surface of the nanoparticle.

Results: Twenty two different kinds of secondary particles were generated by interaction with carbon-12 ion scanning beam in the water phantom. Computed DER at 100 nm from the nanoparticle surface was 4.25, 3.22, 4.28 and 2.89 with Gold, Gadolinium, Platinum and Zinc, respectively. The DER was increased for Au and Pt at larger distance while DER for Gd and Zn was not.

Conclusion: Not only Gold, but also other high atomic number nano materials have potential to be used as radiosensitizer in carbon ion therapy.

Funding Support, Disclosures, and Conflict of Interest: This research was supported by the NRF funded by the Ministry of Science, ICT & Future Planning (2012M3A9B6055201 and 2012R1A1A2042414), Samsung Medical Center grant[GFO1130081]

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