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Development of Radiation Treatment Planning Engine for Proton Boron Fusion Therapy: First Principle Study

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S Kim

S Kim1*, D Yoon2 , H Shin3 , J Jung4 , M Kim5 , K Kim6 , H Jang7 , T Suh8 , (1) Catholic University of Korea, Seoul, Seoul, (4) University of Florida, Gainesville, FL, (7) ST. Marry's Hospital, Seoul, Seoul


SU-I-GPD-T-132 (Sunday, July 30, 2017) 3:00 PM - 6:00 PM Room: Exhibit Hall

Purpose: The purpose of this research is to demonstrate, based on a Monte Carlo simulation code, the procedure of radiation treatment planning for proton boron fusion therapy (PBFT).

Methods: A discrete proton beam (60 – 120 MeV) relevant to the Bragg peak was simulated using a Monte Carlo n-particle extended (MCNPX, Ver. 2.6.0, National Laboratory, Los Alamos NM, USA) simulation code. After computed tomography (CT) scanning of a virtual water phantom including air cavities, the acquired CT images were converted using the simulation source code. We set the boron uptake regions (BURs) in the simulated water phantom to achieve the proton-boron fusion reaction. Proton sources irradiated the BUR, in the phantom. The simulated dose distributions were compared by using the means of percent depth dose (PDD) curves, DVHs and lateral beam profiles at eight depths obtained using the MATLAB code. The acquired dose maps were overlapped with the original CT image of the phantom to analyze the dose volume histogram (DVH).

Results: We successfully confirmed amplifications of the proton doses (average: 130%) at the target regions. From the DVH result for each simulation, we acquired a relatively accurate dose map for the treatment.

Conclusion: A simulation was conducted to characterize the dose distribution and verify the feasibility of PBFT. We observed a variation in proton range and developed a tumor-targeting technique for treatment that was more accurate and powerful than both conventional proton therapy and boron neutron capture therapy.

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