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Electric Energy-Temperature Protocol for Cancer Cell Death with Non-Invasive 13.56 MHz Radiofrequency Hyperthermia

B Prasad

B. Prasad1*, E. B. Seo2, S. Kim2, W. Cho2, J. K. Kim1, (1) Kookmin University, Seoul, Republic of Korea, (2) SMG-Seoul National University Boramae Medical Center, Seoul, Republic of Korea


MO-RPM-GePD-J(B)-4 (Monday, July 31, 2017) 3:45 PM - 4:15 PM Room: Joint Imaging-Therapy ePoster Lounge - B

Purpose: To develop an electric energy-temperature protocol for estimating cancer cell death in a tumor induced mouse with 13.56 MHz radiofrequency hyperthermia for clinical treatment planning.

Methods: A tumor induced nude mouse was considered for the in vivo experiments and 7 mice were considered for heating. An electrode at 13.56 MHz radiofrequency was used as the energy source for tumor heating. Mice were heated two times in a week for two weeks and the power required and temperature increase was measured. Numerical simulations were performed on a CT based computational model to validate the temperature increase with that of experiments. For accurate simulation, dielectric properties and perfusion of tumor were measured and realistic material properties were considered for all body sites. Thermal dose was calculated as cumulative equivalent minutes (CEM 43) to estimate the cancer cell death

Results: Experimental observation indicate that tumor can be selectively heated up to 42°C by keeping normal cells undamaged. The simulation results validate experimental findings and exhibit the effect of properties and perfusion in calculating temperature increase and thermal dose for cancer cell death. An electric energy-temperature protocol with respect to time was developed from the experimental and simulation findings and its shows that a controlled heating can be done over the targeted tumor volume

Conclusion: This work depicts the transient electric energy-temperature protocol for cancer cell death non-invasively. The tumor could be heated selectively to 42°C by keeping surrounding tissue temperature in a normal range. Numerical simulations support the experimental findings by showing the effect of properties and perfusion of tumor volume for estimating the thermal dose. The study would contribute to effective clinical treatment planning for combined radiation and hyperthermia therapy.

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